Peptidases: structure, function and modulation of …
网页2001年12月24日 · Peptidases are enzymes capable of cleaving, and thereby often inactivating, small peptides. They are widely distributed on the surface of many different cell types, with the catalytic site exposed only at the external surface. Peptidases are involved in a variety of processes, including peptide‐mediated inflammatory responses, stromal cell ...
Protease - Wikipedia
网页A protease (also called a peptidase, proteinase, or proteolytic enzyme) [1] is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. [2] They do this by cleaving the peptide bonds within proteins by hydrolysis, a reaction where water ...
Peptidases: Role and Function in Health and Disease
网页2023年4月25日 · Peptidases are involved in the degradation of off-function proteins in lysosomes, cytosol, plasma membranes, or in extracellular space; however, they may also have regulatory roles controlling biological processes crucial for cell homeostasis.
肽酶 - 百度百科
网页肽酶是一种能够水解肽链的酶，是国际生物化学和分子生物学联盟命名委员会（Nomenclature Committee of the International Union of Biochemistry and Molecular Biology，NC-IUBMB）推荐的作为所有蛋白水解酶的一般术语，可以分为两大类型，即内肽酶 (E.C.3.4.21~3.4.99)和外肽酶 (E.C.3.4.11~3. ...
Peptidase - an overview | ScienceDirect Topics
网页Peptidases, also known as proteases, are enzymes that exhibit hydrolytic activity and are present in all living organisms. These enzymes are crucial for various intra- and extracellular processes, but their hydrolytic nature needs to be carefully controlled to prevent harm to the organism. AI generated definition based on: Peptides, 2009.
Proteolytic enzyme | Description, Types, & Functions | Britannica
网页Proteolytic enzyme, any of a group of enzymes that break long chainlike molecules of proteins into peptides and eventually into amino acids. There are two major groups of proteolytic enzymes, exopeptidases and endopeptidases. A well-known endopeptidase in the digestive tracts of animals is pepsin.
Cell-Surface Peptidases - PMC - National Center for Biotechnology ...
网页2004年6月29日 · This review focuses on cell-surface peptidases (ectopeptidases, oligopeptidases) that are involved in the inactivation or activation of extracellular regulatory peptides, hormones, paracrine peptides, cytokines, and neuropeptides.
Regulation of Peptidase Activity beyond the Active Site in Human …
网页2023年12月4日 · Our review focuses on multiple mechanisms and highlights the important role of exosites, allosteric sites, and processes involved in zymogen activation. These mechanisms play a central role in shaping the complex world of peptidase function and are promising potential targets for the development of …
Peptidase - an overview | ScienceDirect Topics
网页1999年3月4日 · Peptidases – also known as proteases, proteinases, and peptide hydrolases – are enzymes best known for catabolizing proteins and polypeptides through the cleavage of peptide bonds (Figure I). Peptidases can be divided into two broad subtypes.
Regulation of Peptidase Activity beyond the Active Site in
网页2023年12月4日 · This comprehensive review addresses the intricate and multifaceted regulation of peptidase activity in human health and disease, providing a comprehensive investigation that extends well beyond the boundaries of the active site. Our review focuses on multiple mechanisms and highlights the important role of exosites, allosteric sites, and ...
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