Human Blood-Brain Barrier Model Blames Pericytes for CAA
2020年6月15日 · Blood-brain barrier model combines human astrocytes, pericytes, and endothelial cells. APOE4 in pericytes, but not the other cells, promoted cerebral amyloid angiopathy. Blocking NFAT signaling protected pericytes. Other researchers called the model an important advance. “This is a very innovative, versatile blood-brain barrier model, with ...
Tunneling Nanotubes—How Pericytes Control Blood Flow
2020年8月19日 · Delicate tubes connecting pericytes on adjoining capillaries coordinate regional blood flow, they find. Tunneling nanotubes connect pericytes on different capillaries in mouse retinae. In response to light, one pericyte constricts its capillary, the other widens. The coordinated action depends on calcium waves traveling through the nanotube.
Pericytes Don’t Go With the Flow—They Change It - ALZFORUM
2017年2月13日 · Pericytes shrink and die in patients with Alzheimer’s disease, and the study supports the idea that the loss of these cells promotes the disease’s pathology. “It makes a direct link between blood flow dysregulation and neuronal degeneration and loss,” Zlokovic told Alzforum. Blood Vessel Basics. Pericytes make their homes on capillaries ...
Finally, a Dye to Visualize Pericyte Function | ALZFORUM
2017年5月23日 · The discovery of a dye that appears to distinguish pericytes came about by accident. Joint first authors Eyiyemisi Damisah and Robert Hill were studying neuronal labels, including the green fluorescent dye NeuroTrace 500/525. This commercially available dye is typically used to identify neurons in fixed brain sections since it binds to Nissl ...
Smooth Muscle Cells, Not Pericytes, Control Brain Blood Flow
2015年6月27日 · Some studies have pointed at pericytes, the cells that line brain capillaries, as the primary determinants of cerebral blood flow, but the findings have been controversial. In the June 25 Neuron, researchers led by Jaime Grutzendler at Yale School of Medicine, New Haven, Connecticut, report that pericytes lack the contractile protein actin, and ...
Aβ Acts Through Pericytes to Throttle Brain Blood Flow
2019年6月22日 · Attwell wondered if pericytes and capillaries might be involved. While the role of pericytes in regulating blood flow is controversial (Feb 2017 news; May 2017 news), Attwell previously found that a subset of these cells contain α-smooth muscle actin and can squeeze capillaries, reducing their diameter (Peppiatt et al., 2006; Hall et al., 2014).
Interpericyte tunnelling nanotubes regulate neurovascular …
2020年8月19日 · Brain pericyte physiology is an emerging field that underlines how our understanding of brain cerebrovascular function, despite great progress, is limited. The field is still developing and the debate about whether capillary pericytes are contractile or not has been ongoing Krogh, 1919 Peppiatt et al. in 2006 Zimmermann Hill et al., 2015 Grant ...
Reconstruction of the human blood-brain barrier in vitro reveals a ...
2020年6月29日 · From conditioned media experiments, they conclude that ApoE secreted from APOE4 pericytes is sufficient to result in increased amyloid accumulation in the iBBB. Bu and colleagues (Yamazaki et al., 2020) also recently reported BBB dysfunction resulting from APOE4 pericytes, where they observed impaired basement membrane formation. However ...
Amyloid β oligomers constrict human capillaries in ... - ALZFORUM
2019年6月22日 · Other neuropathological studies in AD brain tissue have shown loss of pericytes associated with blood-brain barrier (BBB) breakdown and accumulation of Aβ deposits (Sengillo et al. 2013; Halliday et al. 2015). It has also been shown that Aβ intracellular accumulation kills pericytes (Ma et al., 2018; Sagare et al., 2013). Thus, while ...
Exercise Slows Brain Aging in Mice, with a Little Help from ApoE
2015年11月6日 · Immunostaining detected 20 percent fewer pericytes in the cortex, and they covered only half as many of the blood vessels there. Pericytes bolster the blood-brain barrier by preventing transcytosis across endothelial cells that line vessel walls, and they facilitate communication between endothelial cells and astrocytes.