Prodrug - Wikipedia
网页A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. [1][2] Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted (ADME). [3][4]
What Is a Prodrug? How Prodrugs Work, Examples, and More
网页2021年10月25日 · A prodrug is an inactive medication, but once it enters the body, the body turns it into an active form so that the medication can have its intended effect. This article will provide a definition of a prodrug, examples, and explain its use in medicine. Learn more about prodrugs with GoodRx.
Prodrugs - KnowledgeDose
网页2019年8月23日 · A prodrug is an inactive form of a drug that is converted to a pharmacologically active drug within the body by metabolic processes. Prodrugs are used to overcome pharmaceutical and/or pharmacokinetic barriers of drugs that would otherwise limit their therapeutic usefulness, such as, toxicity, lack of delivery to the site of action, …
网页2008年1月25日 · Abstract | Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then...
Prodrugs - SpringerLink
网页2022年1月1日 · Prodrugs are molecules with little or no pharmacological activity in their own right before they are converted to the active drug. Prodrug strategies can be considered a chemistry-enabled tool to overcome deficiencies in the physicochemical properties of a molecule that limit its formulation options or result in suboptimal bioavailability or ...
网页Prodrugs are molecular derivatives of active pharmaceutical ingredi-ents (APIs) with little or no expected biological activity themselves, but they exhibit beneficial properties...
Prodrugs: Challenges and Rewards - SpringerLink
网页Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs.
Prodrugs: pills your body converts into an illicit drug can evade ...
网页2023年7月24日 · Prodrugs are substances that can only cause an effect after being broken down by enzymes in the digestive system or other chemical reactions in the body. While they have legitimate...
Editorial: Prodrug design and therapeutic applications
网页2023年9月21日 · It is estimated that over 10% of all the marketed drugs to now are prodrugs. Herein, we launch this Research Topic on a relatively small scale to summarize the latest important advances and some newly emerging technologies in the design of prodrugs and their therapeutic applications.
Prodrugs (Video) - JoVE
网页Prodrugs are inactive drug precursors that are enzymatically or chemically converted into active drugs within the body. They are mainly metabolized in the liver or at the site of action.