Succinyl-CoA - an overview | ScienceDirect Topics
网页Succinyl CoA synthase (SCS) is a mitochondrial matrix enzyme that catalyzes the reversible synthesis of succinate and ATP (or GTP) from succinyl-CoA and ADP in the tricarboxylic acid (TCA) cycle. This enzyme is composed of an α-subunit (SCS-G) and a β-subunit (SCS-A), encoded by the SUCLG1 and SUCLA2 genes respectively.
Succinate, an intermediate in metabolism, signal transduction, …
网页2016年8月1日 · Succinate is a product of substrate-level phosphorylation materialized in the CAC; it is involved in a macrophage-specific metabolic pathway generating itaconate, and is also a downstream product of the α-ketoglutarate dehydrogenase complex, a heavily regulated multi-subunit complex.
Succinyl-coenzyme A | C25H40N7O19P3S | CID 92133 - PubChem
网页Succinyl-CoA is an omega-carboxyacyl-CoA having succinoyl as the S-acyl component. It has a role as an inhibitor, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a coenzyme A. It is a conjugate acid of a succinyl-CoA(5-).
Mitochondrial TCA cycle metabolites control physiology and …
网页2020年1月3日 · Another intrinsic regulator is succinyl-CoA, which inhibits both citrate synthase and α-KG dehydrogenase to slow the cycle down. Likewise, an increase in OAA inhibits SDH and decelerates the...
Coenzyme A biosynthesis: mechanisms of regulation, function
网页2024年6月13日 · The synthesis of oxygen-carrying haem, which begins in the mitochondria, is initiated by the condensation of glycine with the succinyl group from succinyl-CoA to form 5-aminolevulinic acid...
Succinyl-CoA-based energy metabolism dysfunction in chronic …
网页2022年10月11日 · However, the underlying mechanisms largely remain elusive. Here, using a mouse model in which myocardial infarction (MI) was induced by coronary artery ligation, we show the metabolic basis of mitochondrial dysfunction in chronic HF.
Succinyl-CoA - an overview | ScienceDirect Topics
网页Succinyl-CoA. Succinyl CoA synthase (SCS) is a mitochondrial matrix enzyme that catalyzes the reversible synthesis of succinate and ATP (or GTP) from succinyl-CoA and ADP in the tricarboxylic acid (TCA) cycle.
Succinyl-CoA - an overview | ScienceDirect Topics
网页Additionally, succinyl-CoA is the most common acyl-CoA in the heart. Many of these factors are enzymatic components of the TCA cycle. Li's group used LC-MS/MS to identify parasite peptides enriched by immunopurification with succinyl lysine antibody in Toxoplasma gondii ( Li et al., 2014 ).
Succinyl-CoA Ligase Deficiency: A Mitochondrial ... - Nature
网页Succinyl-CoA ligase deficiency due to an SUCLG1 mutation is a new cause for mitochondrial hepatoencephalomyopathy. This patient presented on the first day of life with pronounced lactic...
Succinyl-CoA:acetate CoA-transferase functioning in the oxidative ...
网页The characterized succinyl-CoA:acetate CoA-transferase encoded by the AHF96498 gene belonged to the OXTC1/family I CoA-transferases; close homologs of this protein were found in all sequenced Desulfurellaceae, suggesting that they all use the CoA-transferase variant of the TCA cycle.
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