Interleukin - StatPearls - NCBI Bookshelf - National Center for ...
2022年8月22日 · Interleukin-2 (IL-2) T cells produce IL-2. The principal targets are T cells. Its primary effects are T-cell proliferation and differentiation, increased cytokine synthesis, potentiating Fas-mediated apoptosis, and promoting regulatory T cell development.
Role of IL-2 in cancer immunotherapy - PMC - PubMed Central …
Interleukin-2 (IL-2) is one of the key cytokines with pleiotropic effects on immune system. It has been approved for the treatment of metastatic renal cell carcinoma and metastatic melanoma.
A systematic review of interleukin-2-based immunotherapies in …
2023年3月31日 · High-dose interleukin-2 (IL-2) was the first approved immunotherapy for treatment of cancer. Apart from activating effector immune cells, IL-2 also stimulates regulatory T (Treg) cells, thus potentially limiting its efficacy as cancer treatment but offering opportunities to treat autoimmune diseases.
Biology and regulation of IL-2: from molecular mechanisms to ... - Nature
2018年8月8日 · An IL-2 superkine that functions independently of IL-2Rα and has enhanced binding to IL-2Rβ was engineered, and this super-IL-2 (denoted H9) resulted in the more efficient expansion of tumour...
The role of interleukin-2 during homeostasis and activation of the ...
2012年2月17日 · Under steady-state resting conditions, interleukin-2 (IL-2) is mainly produced by activated CD4 + T cells in secondary lymphoid organs. The secreted IL-2 is then consumed at the same...
Definition of interleukin-2 - NCI Dictionary of Cancer Terms
One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-2 is made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system.
Interleukins in cancer: from biology to therapy - Nature
2021年6月3日 · Interleukin-2. Although high-dose therapy with IL-2 induced durable complete responses in some patients with melanoma and RCC, it comes with potentially life-threatening adverse events.
Interleukin-2 (Proleukin®, IL-2, Aldesleukin) - OncoLink
Interleukin-2 is a biologic response modifier and immune therapy used in the treatment of metastatic renal cell carcinoma and metastatic melanoma.
IL-2: A Two-Faced Master Regulator of Autoimmunity - PMC
IL-2 is a critical component for Treg development and function and as such it serves as a negative regulator of autoimmunity. However, IL-2 is also well known for its role in T-cell activation and expansion, raising the question as to whether it also promotes autoimmune response. Although the T-cell activation function of IL-2 is well ...
Overview of interleukin-2 function, production and clinical ...
2004年11月7日 · IL-2 exerts a wide spectrum of effects on the immune system, and it plays crucial roles in regulating both immune activation and homeostasis. Both IL-2 and its multipartite receptor are prototypical of the Type I receptor superfamily, and both have been exploited in numerous ways in the clinic.
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