Alteplase Uses, Side Effects & Warnings - Drugs.com
2024年6月3日 · Alteplase is used to treat a stroke caused by a blood clot or other obstruction in a blood vessel. Alteplase is also used to prevent death from a heart attack (acute myocardial infarction). Alteplase is also used to treat a blood clot in the lung (pulmonary embolism).
Cathflo® Activase® (alteplase) Administration
Each time you administer Cathflo, use a single-use 2 milligram vial per lumen, and consult the dosing chart. If catheter function is not restored at 120 minutes after 1 dose of Cathflo, a second dose may be instilled. Studies only evaluated up to 2, 2 milligram doses.
Activase, TPA (alteplase) dosing, indications, interactions, adverse ...
Cathflo Activase: 2 mg in 2 mL instilled into occluded catheter. Assess catheter function after 30 minutes of dwell time by attempting to aspirate blood; if unable to aspirate after 120...
Each reconstituted vial will deliver 2 mg of Cathflo Activase, at a pH of approximately 7.3. Alteplase is an enzyme (serine protease) that has the property of fibrin-enhanced conversion of...
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Alteplase - ASHP
Alteplase is a purified glycoprotein with a specific activity of 580,000 international units/mg. The 50-mg vial contains 29 million international units, and the 100-mg vial contains 58 million international units.1(12/05) Alteplase, an off-white lyophilized powder, becomes a colorless to pale yellow solution on reconstitution.
Alteplase - StatPearls - NCBI Bookshelf
2023年7月10日 · Intravenous alteplase is cleared primarily by the liver with an initial half-life of fewer than 5 minutes and a terminal half-life of 72 minutes. When alteplase 2 mg is instilled into occluded catheters to restore catheter function, it is unlikely that plasma will attain pharmacologic concentrations of alteplase.
2015年2月13日 · Activase is indicated for the treatment of acute ischemic stroke. Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment [see...
Cathflo® Activase® (alteplase) for Catheter Occlusion Treatment
Certain causes of catheter dysfunction should be considered before treatment with Cathflo Activase (e.g. catheter malposition, mechanical failure, constriction by a suture and lipid deposits or drug precipitates within the catheter lumen). These types of conditions should be considered before treatment with Cathflo Activase.
Alteplase: Dosage, Mechanism/Onset of Action, Half-Life
2020年2月17日 · Initiates local fibrinolysis by binding to fibrin in a thrombus (clot) and converts entrapped plasminogen to plasmin. V d (initial): Approximates plasma volume.
TPA Therapy - StatPearls - NCBI Bookshelf
100 mg over 2 hours; may be administered as a 10 mg bolus followed by 90 mg over 2 hours. Ischemic Stroke: The only blood test that is necessary before tPA usage is the blood glucose level. If the patient is on anticoagulation like coumadin, then only we should do PT, PTT, and INR, etc. ... Instill 2 mg of alteplase in the occluded lumen and ...