Microbiology of the Gastrointestinal Tract - Medical Microbiology ...
Anaerobic bacteria predominate. The upper gastrointestinal tract (the stomach, duodenum, jejunum, and upper ileum) normally contains a sparse microflora; the bacterial concentrations is less than 10 4 organisms/ml of intestinal secretions ( Fig. 95-1 ).
Peptostreptococcus anaerobius promotes colorectal ... - Nature
2019年9月9日 · Peptostreptococcus anaerobius (P. anaerobius) is an anaerobic bacterium selectively enriched in the faecal and mucosal microbiota from patients with CRC, but its causative...
A complex human gut microbiome cultured in an anaerobic …
2019年5月13日 · Here, we show the extended coculture of living human intestinal epithelium with stable communities of aerobic and anaerobic human gut microbiota, using a microfluidic intestine-on-a-chip that...
Bacteria, colonic fermentation, and gastrointestinal health
PMID: 22468341. DOI: 10.5740/jaoacint.sge_macfarlane. Abstract. The colonic microbiota plays an important role in human digestive physiology and makes a significant contribution to homeostasis in the large bowel. The microbiome probably comprises thousands of different bacterial species.
A Robust Longitudinal Co-culture of Obligate Anaerobic Gut
2019年2月6日 · The majority of human gut microbiome is comprised of obligate anaerobic bacteria that exert essential metabolic functions in the human colon. These anaerobic gut bacteria constantly crosstalk with the colonic epithelium in a mucosal anoxic-oxic interface (AOI).
Co-occurrence of anaerobic bacteria in colorectal carcinomas
2013年5月15日 · A polymicrobial signature of Gram-negative anaerobic bacteria is associated with colorectal carcinoma tissue. Numerous cancers have been linked to microorganisms. Given that colorectal cancer is a leading cause of cancer deaths and the colon is continuously exposed to a high diversity of microbes, the relationship between gut mucosal microbiome ...
Coculture of primary human colon monolayer with human gut …
2021年6月28日 · For the longer term (hours to days) a device called gut-microbe (GuMI) with anaerobic apical flow and aerobic basal flow maintains an oxygen gradient across the epithelial barrier similar to a ...
Bioengineering approaches to simulate human colon
2021年6月1日 · Several diseases associated to colon microbial imbalance (dysbiosis), such as obesity, diabetes, inflammatory bowel disease, cardiovascular disease and cancer, are being reverted by modulation of gut microbiota composition …
Links between Diet, Intestinal Anaerobes, Microbial Metabolites
2023年5月1日 · The colon is a largely anaerobic ecosystem, although there are oxygen gradients across the colonic wall, with free oxygen rapidly metabolised by facultative anaerobes . The prevailing environmental conditions mean that most colonic bacteria are strict anaerobes.
Development of a Scalable Coculture System for Gut Anaerobes …
2019年8月19日 · We established a simple 2-chamber culture system for human colonic epithelium, termed as Intestinal Hemi-Anaerobic Coculture System (iHACS), consisting of a hypoxic apical chamber and a normoxic basal chamber.