Anthelmintics for drug repurposing: Opportunities and challenges
2021年4月16日 · Anthelmintics are administered by oral drench (as a general route), slow-release bolus, injection, or in-feed (Taylor, 1999). According to previous studies (Davis et al., 2020, Lalthanpuii and Lalchhandama, 2020), transcuticular/tegumental diffusion is an appropriate route for drug entrance into parasitic worms.
Epidemiology and field efficacy of anthelmintic drugs ... - Nature
2024年3月21日 · The anthelmintics tested for efficacy were Albendazole bolus 300 mg, 7.5 mg/kg manufactured by Habei Lihua Pharmaceutical Co., Ltd, China; Tetramisole HCL bolus 600 mg, 15 mg/kg manufactured by...
Development and application of a delayed-release anthelmintic …
Here, we describe the use of a delayed-release anthelmintic delivery system that can be administered when the hosts can be captured and its activity delayed until a more appropriate period in the host-parasite cycle.
Pediatric Ascariasis Medication: Anthelmintic agents - Medscape
2023年10月6日 · Broad-spectrum anthelmintic agent effective against Ascaris species, hookworm, tapeworm, liver fluke, and pinworms. Decreases ATP production in worm, causing energy depletion, immobilization, and...
New oral anthelmintic intraruminal delivery device for cattle
KEY WORDS: Anthelmintic, bolus, cattle, delayed release, eggs, larvae, oral drug delivery device, pulsed release, rumino reticulum device, veterinary parasitology. Over the last few years, a number of different anti-parasite formulas with anthelmintic properties aimed at preventing parasite infestations in ruminants have been developed.
New oral anthelmintic intraruminal delivery device for cattle
Background: The purpose of this work was to develop a new oral drug delivery system intended for cattle and that enables delayed and pulsed release of an anthelmintic agent. Materials: This new tailored dosage form, also called reticulo-rumen device (RRD) has been evaluated on grazing calves by means of measurements of milliunits of tyrosine ...
Photo of the delayed-release intra-ruminal bolus before …
The bolus released a placebo for c. 150 days followed by an anthelmintic drug for c. 30 days (abamectin, MSD Agvet, NZ). Thus, nematodes were eliminated in October ( Carlsson et al., 2012 ).
Development and application of a delayed-release anthelmintic …
2012年3月15日 · We examined the efficacy of an anthelmintic agent (ivermectin, Merck-Agvet) on the parasitic nematodes of free-ranging snowshoe hares (Lepus americanus) during 27 months in southern Manitoba ...
Potential environmental consequences of administration of anthelmintics …
2012年9月30日 · Sheep anthelmintics, veterinary medicines that control gastro-intestinal helminthes, liver fluke and lungworms (Floate et al., 2005), may be applied topically, orally, via intraruminal boluses, by injection or in-feed.
Anthelmintics for drug repurposing: Opportunities and challenges
2021年5月1日 · Anthelmintics are administered by oral drench (as a general route), slow-release bolus, injection, or in-feed (Taylor, 1999). According to previous studies (Davis et al., 2020, Lalthanpuii and Lalchhandama, 2020), transcuticular/tegumental diffusion is an appropriate route for drug entrance into parasitic worms.