Regulation of Respiration and Apoptosis by Cytochrome c …
2019年11月1日 · We propose that, under physiological conditions, Cyt c is phosphorylated, which controls mitochondrial respiration and apoptosis. Under conditions of stress Cyt c phosphorylations are...
Mechanisms of cytochrome c release from mitochondria
2006年5月5日 · In the cytosol, Cyt c mediates the allosteric activation of apoptosis-protease activating factor 1, which is required for the proteolytic maturation of caspase-9 and caspase-3. Activated...
Diverse functions of cytochrome c in cell death and disease
2024年3月23日 · Upon cellular stress, it can be released into the cytosol, where it interacts with apoptotic peptidase activator 1 (APAF1) to form the apoptosome, initiating caspase-dependent apoptotic cell death....
Cytochrome C-Mediated Apoptosis | Annual Reviews
In this pathway, a variety of apoptotic stimuli cause cytochrome c release from mitochondria, which in turn induces a series of biochemical reactions that result in caspase activation and subsequent cell death. In this review, we focus on the recent progress in understanding the biochemical mechanisms and regulation of the pathway, the roles of ...
Regulation of Respiration and Apoptosis by Cytochrome c …
Cytochrome c (Cytc) is a multifunctional protein, acting as an electron carrier in the electron transport chain (ETC), where it shuttles electrons from bc1 complex to cytochrome c oxidase (COX), and as a trigger of type II apoptosis when released ...
Role of Cytochrome c in Apoptosis: Increased Sensitivity to …
2007年1月8日 · Testis Cyt c can promote apoptosis. We evaluated the sensitivity of CRL 2613 and the clones with reintroduced somatic cyt c (CL3 and CL8) to different apoptosis triggers.
In mammalian cells, a major caspase activation pathway is the cyto-chrome c-initiated pathway. In this pathway, a variety of apoptotic stimuli cause cytochrome c release from mitochondria, which in turn induces a series of biochem-ical reactions that …
Mitochondrial control of apoptosis: the role of cytochrome c
1998年8月10日 · Mitochondrial cytochrome c (cyt c) has been found to have dual functions in controlling both cellular energetic metabolism and apoptosis. Through interaction with apoptotic protease activating factors (Apaf), cyt c can initiate the activation cascade of caspases once it is released into the cytosol.
The Molecular Perspective: Cytochrome c and Apoptosis
2004年4月1日 · As shown in Figure 2, cytochrome c and the mitochondria play a central role in apoptosis, signaling the cell to begin the process of programmed cell death. Apoptosis is triggered when something is amiss with the cell: DNA damage, detachment from neighbors, growth factor deprivations, infection, or a host of other signs.
Cytochrome c : the Achilles’ heel in apoptosis - Springer
2011年12月17日 · Accumulating evidence suggests that only unmodified holocytochrome c is efficient in the stimulation of apoptosis. Considering the importance of cytochrome c in both life and death, it was of significant interest to investigate the complete or partial cytochrome c deficiency in vivo.