Cell wall structure and biogenesis in Aspergillus species
2016年9月1日 · Aspergillus species are among the most important filamentous fungi from the viewpoints of industry, pathogenesis, and mycotoxin production. Fungal cells are exposed to a variety of environmental stimuli, including changes in osmolality, temperature, and pH, which create stresses that primarily act on fungal cell walls.
Aspergillus fumigatus - Wikipedia
Aspergillus fumigatus is a species of fungus in the genus Aspergillus, and is one of the most common Aspergillus species to cause disease in individuals with an immunodeficiency. Aspergillus fumigatus , a saprotroph widespread in nature, is typically found in soil and decaying organic matter, such as compost heaps, where it plays an essential ...
Cell wall of Aspergillus fumigatus: Variability and response to stress
2023年7月1日 · The cell wall of A.fumigatus is composed of >90% polysaccharides. The core skeleton is a branched β1,3 glucan linked to chitin, galactomannan, and β1,3-β1,4 glucans. Chemical studies suggest that other polysaccharides, such as α1,3 glucan and mannans, act as a cement, filling the pores between fibrillar polysaccharides (Latgé et al., 2017).
Aspergillus fumigatus morphology and dynamic host interactions
2017年9月18日 · In this Review, we discuss the life cycle of A. fumigatus and the changes that occur in its cell wall that are accompanied by morphological changes. Furthermore, we discuss how A. fumigatus...
A molecular vision of fungal cell wall organization by ... - Nature
2021年11月3日 · Here we compare the cell wall structure of a fungal pathogen Aspergillus fumigatus and four mutants depleted of major structural polysaccharides. High-resolution solid-state NMR spectroscopy...
Structure, Mechanism, and Inhibition of Aspergillus fumigatus ...
2019年2月26日 · We also present the X-ray crystal structure of A. fumigatus TrxR and use in silico modeling of the enzyme-inhibitor complex to outline key molecular interactions. This provides a scaffold for future design of potent and selective antifungal drugs that target TrxR, improving the potency of ebselen toward inhbition of A. fumigatus growth.
The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus …
Aspergillus fumigatus releases abundant airborne conidia which are inhaled by humans. The first barrier involved in the A. fumigatus conidia clearance is formed by the airway mucociliary cells followed by the alveolar macrophages in the alveolar lumen before they undergo germination ( …
Cell Wall of Aspergillus fumigatus : a Dynamic Structure
2008年11月1日 · The fungal cell wall of A. fumigatus is a complex organization of macromolecules resulting from several biosynthetic pathways: protein synthesis in the endoplasmic reticulum (ER), biosynthesis of mannan and glycans in the ER and Golgi complex, and synthesis of homopolysaccharide at the plasma membrane. Molecular biology methods and …
Aspergillus fumigatus - PLOS
2021年8月26日 · Aspergillus fumigatus is a saprophytic, filamentous fungus found in soils and compost and the causative agent of several pulmonary diseases in humans, birds, and other mammals. A. fumigatus and other filamentous fungi grow as networks of filamentous hyphae that have characteristics of a classic microbial biofilm.
Aspergillus fumigatus : Principles of Pathogenesis and Host …
Aspergillus fumigatus is a ubiquitous saprophytic mold (67) that forms airborne spores (conidia). Humans inhale, on average, hundreds of these infectious propagules daily. In immune competent hosts, these encounters are of no further significance—conidia are killed and cleared by cells of the pulmonary immune system.