Emergent synchronous beating behavior in spontaneous beating ...
2021年6月4日 · Synchronization of beating interval is one of the essential dynamic characteristics of cardiomyocytes to provide the blood pumping function of the heart. Goshima explained this...
Mechanical activities of self-beating cardiomyocyte aggregates …
2021年7月26日 · Results. In this section, we describe the mechanical response of human-derived self-beating CSs (Fig. 1 a) observed in two types of tests: (i) compression tests on single CSs and (ii) compression...
Programmed spontaneously beating cardiomyocytes in …
2024年8月1日 · Stem cells have gained attention as a promising therapeutic approach for damaged myocardium, and there have been efforts to develop a protocol for regenerating cardiomyocytes (CMs). Certain cells have showed a greater aptitude for yielding beating CMs, such as induced pluripotent stem cells, embryonic stem cells, adipose-derived stromal ...
Emergent synchronous beating behavior in spontaneous beating ...
2021年6月4日 · Synchronization of beating interval is one of the essential dynamic characteristics of cardiomyocytes to provide the blood pumping function of the heart. Goshima explained this coordinated synchronous behavior as the faster firing regulation of heart beating 1.
Autonomous beating rate adaptation in human stem cell-derived …
2016年1月19日 · Cardiomyocytes adapt their autonomous beating rate to the frequency at which they were stimulated, an effect mediated by the emergence of a rapidly depolarizing cell population, and the...
Robotic manipulation of cardiomyocytes to identify gap junction ...
2024年10月23日 · The system is capable of accurate measurement of each cardiomyocyte’s height in real time, in situ segmentation of cell nucleus regions, and microinjection of spontaneously beating induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) during the temporal resting phase with a constant injection depth across all cells.
The role of c-Jun for beating cardiomycyte formation in prepared ...
2023年12月18日 · In our study, we found for the first time that c-Jun-ko mESCs were strongly directed into differentiating as beating cardiomyocytes during EB formation, suggesting its involvement in cardiomyocyte development.
Spontaneously beating cardiomyocytes derived from white …
2010年1月1日 · In vitro treatment of newly isolated adipocytes or DFAT cells with inhibitors of bone morphogenetic proteins (BMP) and Wnt signalling promoted the development of the cardiomyocyte phenotype as determined by the number or beating colonies of cardiomyocyte-like cells and expression of troponin I, a cardiomyocyte-specific marker.
Autonomous beating rate adaptation in human stem cell-derived ...
2016年1月19日 · Cardiomyocytes adapt their autonomous beating rate to the frequency at which they were stimulated, an effect mediated by the emergence of a rapidly depolarizing cell population, and the expression of hERG. This rate-adaptive behaviour is long lasting and transferable to the surrounding cardiomyocytes.
Biology of the cardiac myocyte in heart disease - PMC
Spontaneously beating cardiomyocytes can be obtained for at least four serial passages without appearing to undergo any dedifferentiation, but serial passaging of these cells does appear to decrease the rapid expansion of the cells.
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