Bispecific monoclonal antibody - Wikipedia
A bispecific monoclonal antibody (BsMAb, BsAb) is an artificial protein that can simultaneously bind to two different types of antigen or two different epitopes on the same antigen. [1] Naturally occurring antibodies typically only target one antigen.
Bispecific Antibodies: An Area of Research and Clinical Applications
Bispecific antibodies (BsAbs) have two distinct binding domains that can bind to two antigens or two epitopes (an antigen part) of the same antigen simultaneously.
The present and future of bispecific antibodies for cancer therapy
2024年3月6日 · Bispecific antibodies (bsAbs) enable novel mechanisms of action and/or therapeutic applications that cannot be achieved using conventional IgG-based antibodies.
Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies
Currently, most BsAbs are T cell-redirecting antibodies, including two FDA-approved molecules (Blinatumomab and Catumaxomab) and an increasing number of next-generation bispecific or multi-specific antibodies.
Bispecific antibodies: design, therapy, perspectives - PMC
Antibodies (Abs) containing two different antigen-binding sites in one molecule are called bispecific. Bispecific Abs (BsAbs) were first described in the 1960s, the first monoclonal BsAbs were generated in the 1980s by hybridoma technology, and the ...
A review of bispecific antibodies and antibody constructs in …
2019年9月1日 · Bispecific antibodies (bsAbs) are antibodies that bind two distinct epitopes to cancer.. For use in oncology, one bsAb has been approved and 57 bsAbs are in clinical trials, none of which has reached phase 3. These bsAbs show great variability in design and mechanism of action. The various designs are often linked to the mechanisms of actions.
Bispecific Antibodies: A Review of Development, Clinical …
Bispecific antibodies (bsAbs) are molecules that recognise two different antigens and are used to engage effector cells, such as T-cells, to kill malignant B-cells.
Bispecific antibodies: a mechanistic review of the pipeline
2019年6月7日 · The term bispecific antibody (bsAb) is used to describe a large family of molecules designed to recognize two different epitopes or antigens. BsAbs come in many formats, ranging from relatively...
Challenges and strategies for next-generation bispecific antibody …
2020年4月20日 · In this review, we mainly discuss previous and current challenges in bsAb development and underscore corresponding strategies, with a brief introduction of several typical bsAb formats.
Bispecific antibodies: advancing precision oncology
2024年10月1日 · Bispecific antibodies (bsAbs) offer a novel approach to anticancer therapy by targeting different antigens via a range of mechanisms of action. Manipulating bsAb structures allows generation of multiple formats to optimize molecular function for specific clinical contexts.