Cytotoxic T-lymphocyte associated protein 4 - Wikipedia
Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses.
Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4 …
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an immune checkpoint molecule that is mainly expressed on activated T cells and regulatory T (Treg) cells that inhibits T-cell activation and regulates immune homeostasis.
CTLA-4: a moving target in immunotherapy - PMC - PubMed …
Cytotoxic T Lymphocyte antigen 4 (CTLA-4) (CD152) and CD28 are homologous receptors expressed by both CD4 + and CD8 + T cells, which mediate opposing functions in T cell activation. Both receptors share a pair of ligands expressed on the surface of …
CTLA-4: a moving target in immunotherapy | Blood | American …
2018年1月4日 · CD28 and CTLA-4 are members of a family of immunoglobulin-related receptors that are responsible for various aspects of T-cell immune regulation. The family includes CD28, CTLA-4, and ICOS as well as other proteins, including PD-1, BTLA, and TIGIT.
Frontiers | Current understanding of CTLA-4: from mechanism to ...
2023年7月10日 · Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is majorly expressed in activated T cells and works as a critical regulator in the inflammatory response.
CTLA-4: new insights into its biological function and use in …
2002年7月1日 · We summarize here recent findings that suggest a previously unrecognized role for CTLA-4 in the regulation of T cell responses.
Molecular and Cellular Functions of CTLA-4 - PubMed
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily, expressed primarily by T-cells.
CTLA-4: From mechanism to autoimmune therapy - ScienceDirect
2020年3月1日 · CTLA-4 has a critical and central role in the regulation of immune responses and induction of self-tolerance. CTLA-4 controls the T-cell activation in the many ways by which is important for protection against autoimmunity.
CTLA-4: Checkpoints beyond the membrane - Cell Press
2024年2月7日 · CTLA-4 is a dimeric receptor upregulated to moderate levels on effector T cells and constitutively highly expressed on regulatory T cells (Tregs).
CTLA-4: From mechanism to autoimmune therapy - PubMed
Inhibitory signals of CTLA-4 suppress T cell responses and protect against autoimmune diseases in many ways. In this review, we summarize the structure, expression and signaling pathway of CTLA-4. We also highlight how CTLA-4 defends against potentially self-reactive T cells.