Cell polarity in development and cancer - Nature Cell Biology
Growing evidence indicates that loss of cell–cell adhesion and cell polarity may also be important in early stages of cancer. The strongest hints in this direction come from studies on...
Epithelial cell polarity, stem cells and cancer - Nature
2011年12月15日 · Loss of epithelial cell polarity — through deregulation of these proteins — is crucial for cancer cell invasion and advanced tumour progression. Accumulating evidence indicates...
Cell polarity changes in cancer initiation and progression
Effects of altered cell polarity on cancer. Major cell polarity protein alterations leads to cancer initiation and progression in their respective organs. The figure highlights the different biological processes affected by the cell polarity alterations that …
Cell polarity changes in cancer initiation and progression
2023年12月13日 · Here, we summarize the recent findings, shedding new light on the involvement of polarity players in cancer development, and discuss the possibility of harnessing cell polarity changes to better predict, diagnose, and cure cancers.
Rewiring cell polarity signaling in cancer | Oncogene - Nature
2014年3月17日 · In this review, we discuss recent advances in our understanding of how polarity proteins regulate diverse signaling pathways throughout cancer progression from initiation to metastasis....
Cell polarity changes in cancer initiation and progression
2024年1月1日 · Cell polarity, which consists of the morphological, structural, and functional organization of cells along a defined axis, is a feature of healthy cells and tissues. In contrast, abnormal polarity is a hallmark of cancer cells. At the molecular level, key evolutionarily conserved proteins that contr …
Cellular and Molecular Mechanisms Underlying Planar Cell Polarity ...
Recent studies have revealed critical contributions of under-appreciated planar cell polarity (PCP) signaling to tumor progression, and suggest that a deeper understanding of this pathway may yield valuable insights into tumor biology and the development of novel therapeutic strategies.
Development and dynamics of cell polarity at a glance - PMC
In this Cell Science at a Glance review and poster, we describe molecular asymmetries that underlie cell polarity in several cellular contexts. We highlight multiple developmental systems that first establish cell/developmental polarity, and then maintain it.
Cell Polarity As A Regulator of Cancer Cell Behavior Plasticity
In this review, we discuss how cell polarity proteins regulate a diverse array of biological processes and how they can contribute to alterations in the behavior of cancer cells. Keywords: morphogenesis, 3D, oncogenes, tumor suppressor.
Par complex in cancer: A regulator of normal cell polarity joins …
2008年11月11日 · Recent findings have identified a regulator of cell polarity, the Par complex, as an important signaling node in tumorigenesis. In normal cell types, the Par complex is part of the molecular machinery that regulates cell polarity and maintains normal cell homeostasis.
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