AMPK regulates cell shape of cardiomyocytes by modulating turnover of ...
网页Mechanical stress elicited by the heart contractility promotes AMPK localization to the intercalated discs, where AMPK regulates microtubule dynamics and cardiomyocyte function. Activated AMPK localizes at the intercalated discs in the heart, a specific cell‐cell junction present between cardiomyocytes.
AMPK: a therapeutic target of heart failure—not only metabolism ...
网页2019年1月1日 · AMPK regulates multiple physiological processes to maintain cardiomyocyte homeostasis. AMPK activation results in regulation of metabolism, protein transportation, transcription factors, and/or coactivators, kinases, and …
The role of AMPK in cardiomyocyte health and survival
网页2016年7月16日 · An important regulator of cardiomyocyte energy homeostasis is adenosine monophosphate-activated protein kinase (AMPK). AMPK is a serine-threonine kinase that functions primarily as a metabolic sensor to coordinate anabolic and catabolic activities in the cell via the phosphorylation of multiple proteins involved in metabolic pathways.
The role of AMPK in cardiomyocyte health and survival
网页2016年12月1日 · An important regulator of cardiomyocyte energy homeostasis is AMP-activated kinase (AMPK). AMPK functions as a metabolic sensor to coordinate cellular anabolic and catabolic processes. AMPK also controls of a variety of processes that contribute to cardiomyocyte health and survival.
Natural AMPK Activators in Cardiovascular Disease Prevention
网页2022年1月3日 · AMP-activated protein kinase (AMPK) activators derived from natural products are promising agents for cardiovascular drug development owning to regulatory effects on physiological processes and diverse cardiometabolic disorders.
AMPK activation counteracts cardiac hypertrophy by reducing O …
网页2018年1月25日 · Here, we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without affecting downstream targets previously suggested to be involved, such as p70 ribosomal S6 protein kinase,...
AMPK regulates cell shape of cardiomyocytes by modulating turnover of ...
网页2021年1月7日 · AMP-activated protein kinase (AMPK) is a multifunctional kinase that regulates microtubule (MT) dynamic instability through CLIP-170 phosphorylation; however, its physiological relevance in vivo remains to be elucidated. In this study, we identified an active form of AMPK localized at the intercalat …
Sustained Activation of AMPK Enhances Differentiation of Human …
网页2020年8月8日 · AMP-activated protein kinase (AMPK) is a master regulator of metabolic activities. We investigated whether AMPK participates in iPSC-derived cardiomyocyte differentiation. We observed that AMPK phosphorylation at Thr172 increased at day 9 but then decreased after day 11 of differentiation to cardiomyocytes.
Activation of AMPK Promotes Maturation of Cardiomyocytes …
网页2021年3月9日 · Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is an energy-sensing protein kinase involved in the regulation of fatty acid oxidation and mitochondrial biogenesis in cardiomyocytes. This study investigated the effects of AMPK on the maturation of hiPSC-CMs.
Irisin protects cardiomyocytes against hypoxia/reoxygenation
网页2022年5月6日 · To investigate whether AMPK associated signaling pathways were involved in irisin's protective effects, cardiomyocytes were pretreated with AMPK inhibitor compound C before irisin pre-treatment...