Understanding cardiomyocyte proliferation: an insight into cell …
网页Cardiomyocyte proliferation and regeneration are key to the functional recovery of myocardial tissue from injury. In the recent years, studies on cardiomyocyte proliferation overturned the traditional belief that adult cardiomyocytes permanently withdraw from the cell cycle activity.
Cardiomyocyte proliferation, a target for cardiac regeneration
网页The existence, in adult mammalian heart, of low but detectable cardiomyocyte proliferative capacities has shifted the target of regenerative therapy toward new therapeutical strategy. Indeed, the stimulation of terminally differentiated cardiomyocyte proliferation represents the main therapeutic approach for heart regeneration.
Cardiomyocyte Proliferation as a Source of New Myocyte …
网页2021年7月21日 · Summary of signaling pathways, cell cycle genes, and extracellular stimuli that induce cardiomyocyte proliferation, as discussed in this review. This includes cell cycle promotors and inhibitors, both the hippo and neuregulin pathways, microRNAs, and metabolic regulators, such as hypoxia and PDK4.
Frontiers | Cardiomyocyte Proliferation and Maturation: Two …
网页2020年10月14日 · Embryonic and fetal cardiomyocytes undergo robust proliferation to form mature heart chambers in order to accommodate the increased workload of a systemic circulation. In contrast, postnatal cardiomyocytes stop dividing and initiate hypertrophic growth by increasing the size of the cardiomyocyte when exposed to increased workload.
Regulation of cardiomyocyte fate plasticity: a key strategy for …
网页2021年1月27日 · These findings provide the theoretical basis of targeting cellular fate plasticity to induce cardiomyocyte proliferation or formation, and also provide the clues for stimulating heart repair...
Cell proliferation fate mapping reveals regional cardiomyocyte cell ...
网页2021年10月1日 · Myocardial infarction and cardiac pressure overload induce regional patterns of cycling cardiomyocytes. Mechanistically, cardiomyocyte cell cycle activity requires the Hippo pathway effector YAP...
Mechanisms of Cardiomyocyte Proliferation and Differentiation …
网页Understanding the mechanisms that drive cardiomyocyte proliferation and differentiation has the potential to advance the understanding and potentially the treatment of different cardiac pathologies, ranging from myopathies, heart failure, to myocardial infarction.
Turning back time: the promise of cardiac regeneration
网页1 天前 · Although this rate of cardiomyocyte turnover is insufficient for meaningful cardiac regeneration, research has revealed that cardiomyocytes can re-enter the cell cycle and that the proliferation ...
Cardiomyocyte proliferation in cardiac development and …
网页Collectively, cardiac regeneration based on cardiomyocyte proliferation is a promising approach for improving adult human cardiac function after injury, but it is important to elucidate the mechanisms arresting mammalian cardiomyocyte proliferation after birth and to utilize better assays to determine formation of new muscle mass.
Cardiomyocyte Proliferation | Circulation Research - AHA/ASA …
网页2017年2月17日 · Regulatory mechanisms of cardiomyocyte proliferation and postn atal cell cycle arrest. Genetic activation of proliferative pathways or inhibition of arrest mechanisms can promote cardiomyocyte cell cycle activity and improve cardiac function after injury in adult mice.
跳至内容