Regulation of chromatin by histone modifications | Cell Research
网页2011年2月15日 · A principle component of chromatin that plays a key role in this regulation is the modification of histones. There is an ever-growing list of these modifications and the complexity of their...
Histone acylations and chromatin dynamics: concepts, …
网页2021年7月5日 · Chromatin architecture can be modified by various post‐translational modifications of histone proteins. For almost 60 years now, studies on histone lysine acetylation have unraveled the contribution of this acylation to an open chromatin state with increased DNA accessibility, permissive for gene expression.
Characterization of histone acylations links chromatin …
网页2017年10月26日 · Acetylation can also influence chromatin function by serving as a binding site for bromodomain-containing remodeling complexes that can directly stimulate trasnscription by recruiting ...
Chromatin Remodeling in Eukaryotes | Learn Science at Scitable
网页In recent years, researchers have discovered a great deal about chromatin remodeling, including the roles that different protein complexes, histone variants, and biochemical modifications...
Balancing chromatin remodeling and histone modifications in ...
网页Chromatin remodelers use the energy of ATP hydrolysis to reposition or evict nucleosomes or to replace canonical histones with histone variants. By regulating nucleosome dynamics, remodelers gate access to the underlying DNA for replication, repair, and transcription.
Regulation of chromatin by histone modifications - PMC
网页2011年2月15日 · Abstract. Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to external cues to regulate the many uses of DNA. A principle component of chromatin that plays a key role in this …
Histone acetylation and chromatin remodeling - PubMed
网页2001年5月1日 · The acetylation of histones has emerged as a regulatory mechanism capable of modulating the properties of chromatin and thus the competence of the DNA template for transcriptional activation. The role of acetylation in chromatin remodeling is therefore of paramount importance to our understanding of gene regulation in vivo.
Histone acetylation and deacetylation – Mechanistic insights …
网页2024年1月10日 · Here, we will review our current understanding of the molecular mechanisms of acetylation and deacetylation engendered by chromatin-modifying complexes, compare and contrast shared features, and discuss some of the pressing questions for future studies.
Chromatin remodeling of histone H3 variants by DDM1 …
网页2023年8月28日 · MGH3 H2A nucleosomes, inherited from pollen, are resistant to remodeling after fertilization. They are eventually replaced in the embryo by H3.3 H2A nucleosomes, but acetylation of histone H4 and other marks of active euchromatin prevent recognition by DDM1.
Regulating Chromatin by Histone Acetylation | SpringerLink
网页2013年1月1日 · Altogether, these studies demonstrate how histone acetylation can facilitate chromatin remodeling and the accessibility of NER factors to UV-induced DNA damage in order to trigger proper DNA damage repair. Double-strand breaks (DSB) are the most deleterious form of DNA damage as they can lead to a loss of genetic material.
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