A serotonergic axon-cilium synapse drives nuclear signaling to …
2022年9月1日 · Using a cilia-targeted serotonin sensor, we show that opto- and chemogenetic stimulation of serotonergic axons releases serotonin onto cilia. Ciliary 5-HTR6 stimulation activates a non-canonical G αq/11 -RhoA pathway, which modulates nuclear actin and increases histone acetylation and chromatin accessibility.
A serotonergic axon-cilium synapse drives nuclear signaling to …
2022年9月1日 · Using a cilia-targeted serotonin sensor, we show that opto- and chemogenetic stimulation of serotonergic axons releases serotonin onto cilia. Ciliary 5-HTR6 stimulation activates a non-canonical G αq/11 -RhoA pathway, which modulates nuclear actin and increases histone acetylation and chromatin accessibility.
A ciliary synapse for “short-circuit” neuromodulation - Cell Press
2022年9月1日 · These axon-cilium synapses (right inset) contain presynaptic serotonin vesicles, which can be released to activate 5-HTR6 receptors on the cilium. 5-HTR6 coupling to Gα G proteins leads to activation of RhoA GTPases and, ultimately, drives changes in chromatin accessibility in the nucleus of the CA1 neuron.
The neuronal cilium – a highly diverse and dynamic organelle …
2024年5月1日 · Neuronal cilia are found adjacent to chemical synapses and axonal segments, and can form axociliary synapses. Cilia are fascinating organelles that act as cellular antennae, sensing the cellular environment. Cilia gained significant attention in the late 1990s after their dysfunction was linked to genetic diseases known as ciliopathies.
Primary cilia signaling in astrocytes mediates development and
2024年8月5日 · Comparative single-cell transcriptomics reveals that primary cilia mediate canonical SHH signaling to modulate astrocyte subtype-specific core features in synaptic regulation, intracellular...
Cilia make connections | Nature Reviews Neuroscience
2022年9月21日 · These axo-ciliary synapses are proposed to provide a shortcut through which neuronal signalling can modify gene expression. A single primary cilium protrudes from the surface of...
Mapping cilia connections in the human brain - Nature
2023年11月13日 · In some cases, cilia were closely associated with the synaptic cleft and (together with axonal, dendritic and astrocytic components) appeared to form part of a tetrapartite synapse. Astrocyte...
A ciliary synapse for “short-circuit” neuromodulation
2022年9月1日 · In a new study, Sheu et al. use cutting-edge electron microscopy and fluorescence imaging techniques to reveal a new type of synapse that enables chemical transmission between serotonergic axons and the primary cilia of hippocampal neurons.
A serotonergic axon-cilium synapse drives nuclear signaling
2021年9月28日 · Using a newly developed cilia-targeted serotonin sensor, we show that optogenetic stimulation of serotonergic axons results in serotonin release onto cilia. Ciliary HTR6 stimulation activates a non-canonical G αq/11 -RhoA pathway. Ablation of this pathway results in nuclear actin and chromatin accessibility changes in CA1 pyramidal neurons.
The Multifaceted Roles of Primary Cilia in the Development of the ...
In this review, we briefly describe the structural features of primary cilia and illustrate how they control cell signaling in the cortex. We then discuss the involvement of primary cilia in neurogenesis, neuron migration and neuronal circuit formation during corticogenesis.