Clone (cell biology) - Wikipedia
A clone is a group of identical cells that share a common ancestry, meaning they are derived from the same cell. [1] Clonality implies the state of a cell or a substance being derived from one source or the other. Thus there are terms like polyclonal —derived from many clones; oligoclonal[2] —derived from a few clones; and monoclonal ...
Clonal evolution in cancer - Nature
2012年1月18日 · Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with...
Clonal colony - Wikipedia
A clonal colony or genet is a group of genetically identical individuals, such as plants, fungi, or bacteria, that have grown in a given location, all originating vegetatively, not sexually, from a single ancestor. In plants, an individual in such a population is referred to as a ramet.
Clonal Definition & Meaning - Merriam-Webster
Cloning is the production of a population of genetically identical cells or of organisms asexually produced by a single cell or organism. Cloning is fundamental to most living things, since the body cells of plants and animals are clones that come from a single fertilized egg.
What to tell your patient with clonal hematopoiesis and why: insights ...
2020年10月1日 · Acquired genetic mutations in hematopoietic stem or progenitor cells can lead to clonal expansion and imbalanced blood cell production. Clonal hematopoiesis is exceptionally common with human aging, confers a risk of evolution to overt hematologic malignancy, and increases all-cause mortality and the risk of cardiovascular disease.
Clonal dynamics of haematopoiesis across the human lifespan
2022年6月1日 · Haematopoiesis in adults less than 65 years of age was massively polyclonal, with high clonal diversity and a stable population of 20,000–200,000 HSC/MPPs contributing evenly to blood production...
The longitudinal dynamics and natural history of clonal …
2022年6月1日 · Our findings characterize the lifelong natural history of clonal haematopoiesis and give fundamental insights into the interactions between somatic mutation, ageing and clonal selection.
The Implications of Clonal Genome Evolution for Cancer Medicine
2013年2月28日 · The conceptual framework of tumor genome clonality is supported by many observations in epithelial and hematologic cancers, showing that tumors are composed of clones and that clonal evolution of...
Cloning - Wikipedia
Cloning is the process of producing individual organisms with identical genomes, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction; this reproduction of an organism by itself without a mate is known as parthenogenesis.
Clonal Heterogeneity and Tumor Evolution: Past, Present ... - Cell …
We emphasize the importance of macro-evolutionary leaps, often involving large-scale chromosomal alterations, in driving tumor evolution and metastasis and consider the role of the tumor microenvironment in engendering heterogeneity and drug resistance.