Cardiac Excitation-Contraction Coupling - CV Physiology
Excitation-contraction coupling (ECC) is the process whereby an action potential triggers a myocyte to contract, followed by subsequent relaxation. The following figure and text summarize some of the key events that occur during cardiac muscle excitation-contraction coupling:
Cardiac excitation–contraction coupling - Nature
2002年1月10日 · Cardiac excitation–contraction coupling is the process from electrical excitation of the myocyte to contraction of the heart (which propels blood out). The...
Models of Excitation–Contraction Coupling in Cardiac Ventricular Myocytes
Excitation–contraction coupling describes the processes relating to electrical excitation through force generation and contraction in the heart. It occurs at multiple levels from the whole heart, to single myocytes and down to the sarcomere.
Cardiac Excitation-Contraction Coupling | SpringerLink
2019年11月2日 · Excitation–Contraction Coupling of Cardiomyocytes. This chapter will provide you with an understanding of the regulation of Ca 2+ in the myocardium, its physiological implication as well as its role in orchestrating myocardial contraction.
Normal excitation–contraction coupling - Springer
2022年10月10日 · Calcium (Ca2+) ions are a key second messenger involved in the rhythmic excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+-handling proteins is required for healthy cardiac function, whereas disruption in any of these can cause cardiac arrhythmias.
Models of cardiac excitation–contraction coupling in ventricular myocytes
2010年7月1日 · Excitation–contraction (EC) coupling is the processes linking electrical excitation which triggers the action potential shown in (A) membrane potential. This leads to calcium mobilization shown in (B) bulk myoplasmic (intracellular) calcium concentration.
Integrative Systems Models of Cardiac Excitation–Contraction Coupling ...
2011年1月7日 · Intracellular calcium (Ca 2+) concentration plays a number of important regulatory roles in the cardiac myocyte. These include excitation–contraction coupling (ECC), 1 intracellular signaling, 2 regulation of mitochondrial function, 3 gene expression, 4 and cell death. 2,5 This review focuses on the role of Ca 2+ in ECC
Recent advances in understanding cardiac contractility in health …
Cardiac myocytes isolated from mice with enhanced SR Ca leak had increased mitochondrial Ca concentration and ROS production in turn affecting the function of the mitochondria and their size. ... Cheng H, Lederer WJ, Cannell MB: Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science. 1993;262(5134 ...
Regulation of excitation-contraction coupling in mouse cardiac myocytes …
2009年8月31日 · The complex chain of events that links action potential (AP) with contraction, known as excitation-contraction (E-C) coupling (for review see ), starts with myocyte membrane depolarization followed by opening of the voltage-gated L …
Mathematical modeling of active contraction of the human cardiac ...
2023年9月1日 · The main objective of this work is to study the Land model in terms of contraction of cardiac myocyte, while also further studying how various parameters of the model, such as the Ca 2+ profile, Tref, TRPN50, β0 and β1 parameters affect active tension generation in myocyte.
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