Glucocorticoid receptor - Wikipedia
The glucocorticoid receptor (GR or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.
Physiology, Cortisol - StatPearls - NCBI Bookshelf
2023年8月28日 · Once cortisol passes through the cell membrane and enters into the cell, it binds to specific receptors in the cytoplasm. In the absence of cortisol, the glucocorticoid receptor binds to an Hsp90 chaperone protein in the cytosol. The binding of cortisol to the glucocorticoid receptor dissociates the Hsp90.
The Biology of the Glucocorticoid Receptor: New Signaling …
Cortisol, the most abundant endogenous glucocorticoid in man, is transported in the blood predominantly bound to corticosteroid-binding globulin (CBG). CBG not only facilitates cortisol distribution but also plays a role in its release to tissues.
Cortisol Receptors - an overview | ScienceDirect Topics
Cortisol receptors are widely represented throughout all areas of the brain, including the limbic area, reticular activating system, and subcortical and cortical areas.
Glucocorticoid Receptor - Endotext - NCBI Bookshelf
2020年11月21日 · The glucocorticoid receptor (GR) is an evolutionally conserved nuclear receptor superfamily protein that mediates the diverse actions of glucocorticoids as a ligand-dependent transcription factor.
Immune regulation by glucocorticoids - Nature Reviews …
2017年2月13日 · Glucocorticoids inhibit inflammation by dampening signal transduction downstream of pattern recognition receptors (PRRs), cytokine receptors and Fcɛ receptors. Glucocorticoids promote the ...
Genomic and epigenomic mechanisms of glucocorticoids in the …
2017年9月1日 · Glucocorticoids are essential signalling molecules that bind to the glucocorticoid receptor to regulate the brain's ability to adapt to stress. The glucocorticoid receptor can alter neuronal...
Glucocorticoid and Mineralocorticoid Receptors in the Brain: A ...
The main glucocorticoid in humans is cortisol, whereas in rodents it is corticosterone [3]. An important target organ is the brain, where the action of these corticosteroids is mediated by the high-affinity mineralocorticoid receptor (MR) and the lower affinity glucocorticoid receptor (GR).
Glucocorticoid Receptor: Isoforms, Functions, and Contribution to ...
2024年3月29日 · Essential Points. The glucocorticoid receptor, through expression of isoforms, interaction with cofactors, interaction with DNA and RNA, and interaction with other transcription factors, plays a key role in glucocorticoid sensitivity and tissue-selective action.
Glucocorticoid receptor control of transcription: precision and ...
2017年1月5日 · The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many distinct gene networks, each uniquely determined by particular cellular...