The biogenesis, biology and characterization of circular RNAs
网页2019年8月8日 · Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by specific cis...
Cellular origins of dsRNA, their recognition and consequences
网页2021年11月23日 · In this Review, we describe mechanisms by which immunostimulatory dsRNAs are generated in mammalian cells, either by viruses or by the host cells, and how cells respond to them, with the focus on...
Circular RNAs: Characterization, cellular roles, and applications
网页2022年5月17日 · Liu and Chen review the growing toolbox to characterize circular RNA, the resulting emerging understanding of their biological roles, and how circular RNA are being utilized for biomedical applications.
Engineering circular RNA for enhanced protein production
网页2022年7月18日 · Circular RNAs (circRNAs) are stable and prevalent RNAs in eukaryotic cells that arise from back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode proteins, raising the promise...
Circular RNAs: diversity of form and function - PMC
网页Circular RNAs can function as templates for viroid and viral replication, as intermediates in RNA processing reactions, as regulators of transcription in cis, as snoRNAs, and as miRNA sponges. Herein, we review the breadth of circular RNAs, their biogenesis and metabolism, and their known and anticipated functions.
Cellular origins of dsRNA, their recognition and consequences
网页In this Review, we describe mechanisms by which immunostimulatory dsRNAs are generated in mammalian cells, either by viruses or by the host cells, and how cells respond to them, with the focus on recent developments regarding the role of cellular dsRNAs in immune modulation.
The design and synthesis of circular RNAs - PubMed
网页Circular RNAs (circRNAs) are a novel class of RNAs distinguished by their single-stranded, covalently-closed topology. Although initially perceived as rare byproducts of aberrant splicing, circRNAs are now recognized as ubiquitously expressed and …
Circular RNA—Is the Circle Perfect? - PMC - National Center for ...
网页2021年11月24日 · Circular RNA (circRNA) is a distinct class of non-coding RNA produced, in principle, using a back-splicing mechanism, conserved during evolution, with increased stability and a tissue-dependent expression. Circular RNA represents a functional molecule with roles in the regulation of transcription and splicing, microRNA sponge, and the ...
Circular RNA: metabolism, functions and interactions with proteins
网页2020年12月14日 · Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functio …
Circular RNA - Wikipedia
网页In molecular biology, circular RNA (or circRNA) is a type of single-stranded RNA which, unlike linear RNA, forms a covalently closed continuous loop. In circular RNA, the 3' and 5' ends normally present in an RNA molecule have been joined together. This feature confers numerous properties to circular RNA, many of which have only recently been ...