EZH2 - Wikipedia
网页Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression. [5] EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, [6] by using the cofactor S-adenosyl-L-methionine.
EZH2: a novel target for cancer treatment - PubMed
网页2020年7月28日 · In this review, we summarize the structure and action modes of EZH2, focusing on up-to-date findings regarding the role of EZH2 in cancer initiation, progression, metastasis, metabolism, drug resistance, and immunity regulation. Furtherly, we highlight the advance of targeting EZH2 therapies in experiments and clinical studies.
医药魔方 | EZH2：表观遗传，枯树逢春 - 知乎 - 知乎专栏
网页2023年3月24日 · EZH2（enhancer of zeste homolog）全称为“调味增强子同源物2”，属于PcG蛋白（Polycomb group protein）中关键成员之一, 也是pRC2（Polycomb Repressive Complex 2，多梳抑制复合体2）的核心亚基之一，具有组蛋白甲基化转移酶活性, 在表观遗传修饰过程中扮演重要角色。. 前列腺癌 ...
基于表观遗传的肿瘤免疫药物：EZH2抑制剂的研究进展
网页2023年1月15日 · Valemetostat （Ezharmia）是一种强效、选择性、小分子抑制剂，旨在通过靶向EZH1和EZH2对抗表观遗传失调。它是全球第一个获得监管批准的EZH1/EZH2双重抑制剂，用于治疗复发或难治性成人 T 细胞白血病/淋巴瘤 (ATL)。
EZH2 Gene - GeneCards | EZH2 Protein | EZH2 Antibody
网页2024年8月6日 · GeneCards Summary for EZH2 Gene. EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit) is a Protein Coding gene. Diseases associated with EZH2 include Weaver Syndrome and Heyn-Sproul-Jackson Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening …
EZH2: a novel target for cancer treatment | Journal of Hematology ...
网页2020年7月28日 · In this review, we summarize the structure and action modes of EZH2, focusing on up-to-date findings regarding the role of EZH2 in cancer initiation, progression, metastasis, metabolism, drug resistance, and immunity regulation. Furtherly, we highlight the advance of targeting EZH2 therapies in experiments and clinical studies.
EZH2: biology, disease, and structure-based drug discovery
网页2013年12月23日 · EZH2-mediated methylation is a potential independent mechanism for epigenetic silencing of tumor suppressor genes in cancer. Recent studies have found that EZH2 is...
EZH1/2 as targets for cancer therapy | Cancer Gene Therapy - Nature
网页2022年11月11日 · The enhancer of zeste homolog 2 (EZH2) and its highly related homolog EZH1 are considered to be epigenetic silencing factors, and they play key roles in the growth and differentiation of cells as...
EZH2: biology, disease, and structure-based drug discovery
网页2013年12月23日 · EZH2-mediated methylation is a potential independent mechanism for epigenetic silencing of tumor suppressor genes in cancer. Recent studies have found that EZH2 is overexpressed in a wide range of cancers such as those of the prostate, breast, and bladder, which makes EZH2 an attractive anti-cancer drug target.
Targeting EZH2 in cancer - Nature Medicine
网页2016年2月4日 · EZH2, a histone methyl transferase subunit of a Polycomb repressor complex, is recurrently mutated in several forms of cancer and is highly expressed in numerous others. Notably, both...