A network map of endothelin mediated signaling pathway
网页2020年9月11日 · The endothelin signaling pathway depicts the activation of EDNRA to be dependent on either G protein or β-arrestin. The binding of endothelin ligands to EDNRA and EDNRB receptor induces the activation of G-proteins- including G protein subunit alpha Q (GNAQ), G protein subunit alpha 12 and 13 (GNA12 and GNA13).
Endothelin 3/EDNRB signaling induces thermogenic ... - Nature
网页2024年8月22日 · 1 Altmetric. Metrics. Abstract. Thermogenic adipose tissue, consisting of brown and beige fat, regulates nutrient utilization and energy metabolism. Human brown fat is relatively scarce and...
Endothelin receptor B enhances liver injury and pro ... - Nature
网页2022年11月17日 · These findings suggested EDNRB loss or inhibition weakened liver injury and pro-inflammatory responses by down-regulating GRK2 and inhibiting the NF-κB pathway in PBC mice.
News from the endothelin-3/EDNRB signaling pathway: Role ... - PubMed
网页2018年12月1日 · In this review, we will summarize the known functions of the EDN3/EDNRB pathway during neural crest development, with a specific focus on recent scientific advances, and the enteric nervous system in normal and pathological conditions.
News from the endothelin-3/EDNRB signaling pathway: Role …
网页2018年12月1日 · The lethal phenotype of the Ednrb mutant was efficiently rescued by driving expression of Ednrb transgene with the human dopamine-b-hydroxylase (Dbh) promoter, known to drive expression in neural enteric progenitors once the NC cells reach the gut wall (Kapur et al., 1992).
Endothelins (EDN1, EDN2, EDN3) and their receptors (EDNRA, EDNRB …
网页2019年11月1日 · Activation of multiple mitogen-activated protein kinase signal transduction pathways by the endothelin B receptor requires the cytoplasmic tail
Role of endothelin receptor type B (EDNRB) in lung adenocarcinoma
网页2020年5月12日 · Functional investigation of endothelin receptor type B (EDNRB) in lung adenocarcinoma (LUAD) MAPK signaling pathway, pathways in cancer, PI3K‐Akt signaling pathway. EDNRB could inhibit proliferation of H1299 cells
Targeting the endothelin axis as a therapeutic strategy for oral …
网页2020年11月30日 · EDNRB transduction at MOI 50 produced the strongest inhibitory effect on invasion without significant cellular death (determined through preliminary experiments at higher MOI doses).
Endothelins (EDN1, EDN2, EDN3) and their receptors (EDNRA, EDNRB …
网页2019年11月1日 · The results showed that: 1) chicken (c-) EDN1, EDN2, and EDN3 cDNAs were predicted to encode bioactive EDN peptides of 21 amino acids, which show remarkable degree of amino acid sequence identities (91-95%) to their respective mammalian orthologs; 2) chicken (c-) EDNRA expressed in HEK293 cells could be preferentially activated by chicken EDN1 a...
Endothelin receptor B enhances liver injury and pro-inflammatory ...
网页2022年11月17日 · EDNRB overexpression or activation induced liver damage by increasing GRK2 expression and activating NF-κB pathway in wild-type mice. The experiment was divided into 4 groups: Ad-EDNRB adenoviruses (Ad-EDNRB), EDNRB agonist IRL-1620 TFA (EDNRB agonist), normal saline (NaCl), control adenoviruses (Control).
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