Embryonic genome instability upon DNA replication timing …
2024年8月28日 · A single-cell genome-wide DNA replication atlas of pre-implantation mouse embryos reveals an abrupt replication program switch accompanied by a transient period of genomic instability.
Human embryonic development - Wikipedia
Human embryonic development or human embryogenesis is the development and formation of the human embryo. It is characterised by the processes of cell division and cellular differentiation of the embryo that occurs during the early stages of development.
DNA replication in early mammalian embryos is patterned
2024年6月19日 · To evaluate the ability of preimplantation embryos to activate dormant origins, we incubated 1-cell embryos in low concentrations of aphidicolin during the first S-phase and determined DNA ...
Epigenetic regulation of early human embryo development
2023年12月7日 · Recent studies have now produced the first epigenetic maps of early human embryogenesis, stimulating new ideas about epigenetic reprogramming, cell fate control, and the potential mechanisms underpinning developmental plasticity in human embryos.
Personhood status of the human zygote, embryo, fetus - PMC
The development of a zygote into a blastocyst, then to morula, and finally into an embryo and fetus occurs in a very highly regulated, precise, and specific fashion. This is due to transcriptional and translational regulation of genetic material. Certain genes in the genome are only active at precise stages of a developing human organism.
Human embryo live imaging reveals nuclear DNA shedding …
Live imaging of human embryos unveils differences from mouse development and reveals DNA shedding from trophectoderm cell nuclei associated with mechanical stress from blastocyst expansion and biopsy for preimplantation genetic testing.
Regulation of DNA Replication in Early Embryonic Cleavages
2017年1月19日 · Initiation of DNA replication in early embryos has been best studied and characterized in the clawed frog Xenopus laevis, mainly thanks to the development of cell-free extracts capable of recapitulating all the sequential steps of DNA synthesis leading to the formation of functional replication forks ( for review). The exceptional performance ...
Single-cell DNA methylome sequencing of human preimplantation embryos
2017年12月18日 · Here we performed single-cell DNA methylome sequencing for human preimplantation embryos and found that tens of thousands of genomic loci exhibited de novo DNA methylation.
Placeholder Nucleosomes Underlie Germline-to-Embryo DNA …
2018年2月22日 · Here, we provide the mechanism by demonstrating that “Placeholder” nucleosomes, containing histone H2A variant H2A.Z (FV) and H3K4me1, virtually occupy all regions lacking DNA methylation in both sperm and cleavage embryos and reside at promoters encoding housekeeping and early embryonic transcription factors.
DNA and the Developing Embryo - Exploratorium
DNA and the Developing Embryo Inside almost every cell in every living organism is a long, twisted, ladder-like molecule known as DNA. The information contained in the DNA molecule provides a "blueprint," or a set of codes, for building other molecules used by the cell.
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