MAPK/ERK pathway - Wikipedia
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
ERK signalling: a master regulator of cell behaviour, life ...
2020年6月23日 · The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream components of a phosphorelay pathway that conveys growth and mitogenic signals largely channelled by the...
ERK/MAPK signalling pathway and tumorigenesis - PMC
The Ras/Raf/MAPK (MEK)/ERK pathway is the most important signalling cascade among all MAPK signal transduction pathways, and plays a crucial role in the survival and development of tumour cells. The present review discusses recent studies on Ras and ERK pathway members.
ERK signalling: a master regulator of cell behaviour, life and fate
The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream components of a phosphorelay pathway that conveys growth and mitogenic signals largely channelled by the small RAS GTPases.
ERK/MAPK signalling pathway and tumorigenesis - PubMed
The Ras/Raf/MAPK (MEK)/ERK pathway is the most important signalling cascade among all MAPK signal transduction pathways, and plays a crucial role in the survival and development of tumour cells. The present review discusses recent studies on Ras and ERK pathway members.
The extracellular signal-regulated kinase (ERK) pathway
Schematic diagram showing (A) the general signaling pathway for activation of mitogen-activated protein kinases and (B) the specific pathway for activation of extracellular signal-regulated kinase. Abbreviations: ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; MEK, mitogen-activated protein kinase.
ERK1/2 in immune signalling - PMC - PubMed Central (PMC)
Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a diverse array of signalling pathways for shaping cell behaviour and fate.
ERK pathway agonism for cancer therapy - Nature
2024年3月14日 · At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp). Inhibitors targeting various effectors within the ERKp have been developed and explored for over two...
MAPK/ERK Pathway - an overview | ScienceDirect Topics
The ERK signaling pathway is a highly conserved kinase cascade, abundantly expressed in the central nervous system. MEK/ERK signaling cascade has been reported to regulate neuronal functioning by phosphorylating certain transcription factors, motor and exocytosis proteins (Cammarota et al., 2008).
The MEK/ERK cascade: from signaling specificity to diverse
The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of various cellular processes such as proliferation, differentiation, development, learning, survival and, under some conditions, also apoptosis.