Flupirtine - Wikipedia
网页Flupirtine is an aminopyridine that functions as a centrally acting non- opioid analgesic that was originally used as an analgesic for acute and chronic pain [5] but in 2013 due to issues with liver toxicity, the European Medicines Agency restricted its use to acute pain, for no more than two weeks, and only for people who cannot use other paink...
氟吡汀 - 百度百科
网页氟吡汀，氟吡汀是作为中枢作用的非阿片样镇痛药的氨基吡啶。. 它于1984年首次在欧洲上市，主要以Katadolon，Trancolong，Awegal，Efiret，Trancopal Dolo和Metanor等名称销售。.
Flupirtine: Clinical pharmacology - PMC - National Center for ...
网页Flupirtine is neither an opioid nor a non steroidal anti-inflammatory drug (NSAID) producing its analgesic action through blockade of glutamate N-methyl-D-aspartate receptor. It is devoid of adverse effects of routinely used analgesic drugs, but is equally efficacious in reducing pain sensation.
Flupirtine: Uses, Interactions, Mechanism of Action - DrugBank …
网页2008年3月19日 · Flupirtine is a pyridine derivative that is in clinical use as a nonopioid analgesic. It was approved for the treatment of pain in 1984 in Europe. It is not approved for use in the U.S. or Canada, but is currently in phase II trials for the treatment of fibromyalgia. Type. Small Molecule. Groups. Investigational. Structure. 3D. Download.
马来酸氟吡汀 - 百度百科
网页马来酸氟吡汀是一种新型的 止痛药，其作用机制是一种选择性神经原钾通道开放剂 (Selective Neuronal Potassium Channel Opener, SNEPCO)，具有止痛，肌肉松弛和神经保护三重功效。. 主要用于各种类型的中等程度的急性疼痛的治疗，如外科手术、创伤等引起的疼痛以及头 …
Flupirtine, a re-discovered drug, revisited | Inflammation Research
网页2013年1月16日 · Flupirtine is the first therapeutically used K V 7 channel activator with additional GABA A ergic mechanisms and thus the first representative of a novel class of analgesics. The presently accepted main mode of its action, potassium K V 7 (KCNQ) channel activation, opens a series of further therapeutic possibilities.
Flupirtine in pain management: pharmacological properties and …
网页Flupirtine is a centrally acting, non-opioid analgesic that is available in a number of European countries for the treatment of a variety of pain states. The therapeutic benefits seen with flupirtine relate to its unique pharmacological properties. Flupirtine displays indirect NDMA receptor antagoni ….
Role of Flupirtine in the Treatment of Pain - Chemistry and its …
网页2011年11月16日 · Flupirtine is a centrally-acting, non-opioid analgesic with N-methyl-D-aspartate (NMDA) receptor antagonist property which has been shown to be effective in the management of post-operative pain. It is also effective in other painful conditions in which the primary requirement for analgesia is without sedation or anti-inflammatory effects.
Flupirtine: Clinical pharmacology : Journal of Anaesthesiology …
网页Studies suggest flupirtine as an effective analgesic for treatment of acute pain states such as postoperative pain, traumatic injury, headache, and migraine, as well as chronic pain such as musculoskeletal pain. It is effective and better tolerated for treatment of cancer pain.
Flupirtine: pharmacology and clinical applications of a nonopioid ...
网页Background: Flupirtine is a nonopioid drug without antipyretic or antiphlogistic properties and with a favorable tolerability. It constitutes a unique class within the group of nonsteroidal analgesics and displays a peculiar pharmacodynamic profile that invites the investigation of applications beyond the pain-relieving effect.