GMP-140 - 百度百科
血小板α-颗粒膜蛋白（α-granule membrane protein-140，颗粒膜蛋白-140）是血小板活化释放的特异标志之一，可反映体内血小板的活化程度及血栓形成倾向，为人类 血栓性疾病 的早期诊断、治疗提供了一条新的途径，对其它疾病的诊断也具有重要的价值。
血小板颗粒膜蛋白140测定 - 百度百科
血小板颗粒膜蛋白140测定( gmp - 140) 为对血小板细胞粘附受体进行测定是否存在异常, gmp - 140在凝血酶、组胺、补体c5b9等刺激下，α颗粒体和棒状小体膜迅速与胞膜融合而在细胞膜上表达，介导白细胞与内皮细胞的起始黏附，介导血小板与多种白细胞的结合，在 ...
什么是P-选择素（CD62P）？ - 知乎
2021年7月1日 · P-选择素，又名CD62P、颗粒膜蛋白140 (GMP-140)和血小板活化依赖的颗粒外膜蛋白 (PADGEM)，是一种细胞表面糖蛋白，在淋巴细胞迁移到组织过程中发挥关键作用。. P-选择素由一个EGF样结构域、一个氨基末端C型凝集素结构域、一个跨膜结构域、一个短的胞质域和9个 …
颗粒膜蛋白-140 - 百度百科
血小板α-颗粒膜蛋白是血小板活化释放的特异标志之一，可反映体内血小板的活化程度及血栓形成倾向，为人类血栓性疾病的早期诊断、治疗提供了一条新的途径，对其它疾病的诊断也具有重要的价值。. 名 称. 颗粒膜蛋白-140. 所属分类.
血小板颗粒膜蛋白-140研究进展（文献综述） | Semantic Scholar
血小板α-颗粒膜蛋白(α-granule membrane protein．GMP-140)是血小板活化脱颗粒反应中α-颗粒释放后的遗留产物。 测定GMP-140可直接了解血小板的活化程度，可作为血栓性疾病的体外诊断指标，也可作为代谢性疾病．自身免疫性疾病等体内血小板活化程度的特异性指标。
GMP-140: a receptor for neutrophils and monocytes on activated …
GMP-140 is a receptor for neutrophils and monocytes when it is expressed on activated platelets and endothelium. This property facilitates rapid adhesion of leukocytes to endothelium at regions of tissue injury as well as platelet-leukocyte interactions at sites of inflammation and hemorrhage.
GMP‐140: A receptor for neutrophils and monocytes on activated ...
GMP-140 is a receptor for neutrophils and monocytes when it is expressed on activated platelets and endothelium. This property facilitates rapid adhesion of leukocytes to endothelium at regions of tissue injury as well as platelet-leukocyte interactions at sites of inflammation and hemorrhage.
Structure of the human gene encoding granule membrane protein-140…
Here we describe the organization of the human gene encoding GMP-140, which spans over 50 kilobase pairs and contains 17 exons. Almost all exons encode distinct structural domains, including the lectin-like domain, the epidermal growth factor-like domain, each of the nine consensus repeats, and the transmembrane region.
GMP-140, a platelet alpha-granule membrane protein, is also ... - PubMed
We used an immunoperoxidase procedure to examine the tissue distribution of the platelet alpha-granule membrane protein, GMP-140. In addition to its presence in megakaryocytes and platelets, GMP-140 antigen was found in vascular endothelial cells of diverse human organs, but it was not detected in o ….
GMP-140 binds to a glycoprotein receptor on human neutrophils …
GMP-140 is a rapidly inducible receptor for neutrophils and monocytes expressed on activated platelets and endothelial cells. It is a member of the selectin family of lectin-like cell surface molecules that mediate leukocyte adhesion. We used a radioligand binding assay to characterize the interaction of purified GMP-140 with human neutrophils.