Lectin-glycan interactions: a comprehensive cataloguing of cancer ...
This comprehensive review meticulously compiles data on an array of lectins and their interactions with different cancer types through specific glycans. Crucially, it establishes the link between aberrant glycosylation and cancer types. This repository of lectin-defined glycan signatures, assumes paramount importance in the realm of cancer and ...
Lectins as potential tools for cancer biomarker discovery from ...
They found that lectins E-PHA and L-PHA bind to cancer-related N-glycans, while lectin AAL binds to fucose glycans. In another comparative study, lectin/immune-transmission microscopy (TEM) and ion-exchange chromatography (IEC) were applied to detect differential surface display of sialylated and mannosylated glycan moieties on seminal ...
The clinical impact of glycobiology: targeting selectins ... - Nature
2021年1月18日 · In this section, we review glycan neoantigens in cancer and strategies deployed to target them, including vaccines, monoclonal antibodies and CAR T cells. Glycosylation is a hallmark of disease
Lectin biosensors in cancer glycan biomarker detection
2019年1月1日 · Lectin-based biosensors have been developed for the detection of specific aberrant and cancer-associated glycostructures to aid diagnosis, prognosis and treatment assessment of these patients. The attractive features of biosensors, such as portability and simple use make them highly suitable for POC testing.
Lectin-Based Approaches to Analyze the Role of Glycans and …
Lectin-based approaches remain a valuable tool for analyzing glycosylation, especially when detecting cancer-related changes. Certain glycans function as platforms for cell communication, signal transduction, and adhesion. Therefore, the functions of glycans are important considerations for clinical aspects, such as cancer, infection, and immunity.
Glycan–Lectin Interactions in Cancer and Viral Infections and …
2021年9月30日 · Lectins and their glycan interaction partner physiologically, in cancer and viral infections. The lectin subtypes MGL (a), DC-SIGN (b), and selectins (c) belong to the C-type lectin receptors (CLRs) and consist of a carbohydrate recognition domain (CRD) at the end of their extracellular domain as well as a transmembrane and a cytoplasmatic tail.
Thermophoretic glycan profiling of extracellular vesicles for triple ...
2024年3月14日 · Here the authors develop a lectin-based thermophoretic assay (EVLET) that combines vibrating membrane filtration and thermophoretic amplification for efficient extracellular vesicle (EV) glycan...
Glycan–Lectin Interactions in Cancer and Viral Infections and …
2021年9月30日 · Glycan–lectin interactions play an essential role in different cellular processes. One of their main functions is involvement in the immune response to pathogens or inflammation. However, cancer cells and viruses have adapted to avail themselves of these interactions.
Glycan diversity in ovarian cancer: Unraveling the immune …
In addition, within heterospheroids, ovarian cancer stem cells (CSCs) are responsible for driving the increased expression of the M2 macrophage marker CD206 compared with that in bulk ovarian cancer cells. CD206 is a C-type lectin that binds high-mannose glycans, implying a fundamentally more immunosuppressive program.
Emerging applications of lectins in cancer detection and …
2020年1月1日 · Lectins serve as the major molecular tools for glycan profiling. Their application as nano tools is getting impedance for the diagnosis and treatment of cancer. Lectin conjugated drug delivery systems are recognized, bound, and internalized by aberrant sugar present on the cancerous cell surface.