Viral quasispecies of hepatitis B virus in patients with YMDD …
网页2019年2月11日 · The baseline viral QS of HBV in patients with YMDD mutations may not predict the efficacy of combination therapy with LAM/ADV in LAM-resistant patients. In addition, no specific HBV mutant was selected during rescue treatment with LAM/ADV for LAM resistance.
The Naturally Occurring YMDD Mutation among Patients …
网页2012年3月27日 · Several recent reports have demonstrated that tyrosine (Y)-methionine (M)-aspartic acid (D)-aspartic acid (D) (YMDD) motif mutations can naturally occur in chronic HBV patients without antiviral treatment such as lamivudine therapy.
YMDD variants of HBV DNA polymerase gene: Rapid detection …
网页2005年5月5日 · HBV DNA in a conserved polymerase domain (the YMDD locus) was amplified from serum of each patient by PCR and sequenced. HBV genotypes were analyzed by restriction fragment length polymorphism (RFLP) of the PCR products generated from a fragment of the polymerase gene.
YMDD motif mutations in chronic hepatitis B antiviral treatment …
网页2012年5月1日 · This study aimed to determine the natural prevalence of variants of tyrosinemethionine- aspartic acid-aspartic acid (YMDD) motif in patients with chronic hepatitis B (CHB), and to explore its relation with demographic and clinical features, hepatitis B virus (HBV) genotypes, and HBV DNA levels.
YMDD motif mutations in chronic hepatitis B antiviral ... - PubMed
网页Objective: This study aimed to determine the natural prevalence of variants of tyrosine-methionine-aspartic acid-aspartic acid (YMDD) motif in patients with chronic hepatitis B (CHB), and to explore its relation with demographic and clinical features, hepatitis B virus (HBV) genotypes, and HBV DNA levels.
The naturally occurring YMDD mutation among patients ... - PubMed
网页Background: Several recent reports have demonstrated that tyrosine (Y)-methionine (M)-aspartic acid (D)-aspartic acid (D) (YMDD) motif mutations can naturally occur in chronic HBV patients without antiviral treatment such as lamivudine therapy. This paper aims to assess the overall spontaneous incidence and related risk factors of YMDD-motif ...
乙型肝炎病毒YMDD变异株的检测及其临床意义 - 百度学术
网页乙型肝炎病毒YMDD变异株的检测及其临床意义. 目的:检测慢性乙型肝炎患者的HBV多聚酶基因YMDD变异情况,分析相关临床资料;探讨YMDD变异现象究竟是药物诱导的病毒变异,还是体内原有与野生株共存的少量变异株的大量复制.方法:采用基因芯片法检测50例慢性乙型肝炎 ...
Frontiers | Inflammation Pharmacological Reaction and YMDD …
网页2021年4月14日 · Serum hepatitis B virus (HBV) DNA level in patients with YMDD mutants were significantly higher than that in control and negative groups. Serum HbsAg and HbeAg in patients with YMDD mutants were also higher than those in control and negative groups, despite no significant difference was found forserum HbeAb.
Compensatory variances of drug-induced hepatitis B virus YMDD …
网页2016年8月12日 · To deeply reveal molecular characters of HBV evolution under the special condition, here we made a comprehensive investigation of the molecular variation of the 3432 wild-type sequences and 439 YMDD variants from HBV genotype A, B, C and D, and evaluated the co-variant patterns and the frequency distribution in the different YMDD mutation types ...
The Naturally Occurring YMDD Mutation among Patients …
网页2012年3月27日 · Several recent reports have demonstrated that tyrosine (Y)-methionine (M)-aspartic acid (D)-aspartic acid (D) (YMDD) motif mutations can naturally occur in chronic HBV patients without antiviral treatment such as lamivudine therapy.
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