Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma
网页2021年7月27日 · Mitoribosomal defects cause OXPHOS impairment, mitochondrial dysfunction, and increased production of ROS, which are associated with HCC progression in mouse models and human HCC patients. In this paper, we focus on the role of mitochondrial metabolic signatures in the development and progression of HCC.
Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma
网页2021年7月27日 · HCC progression and metastasis are closely related to altered mitochondrial metabolism, including mitochondrial stress responses, metabolic reprogramming, and mitoribosomal defects. Mitochondrial oxidative phosphorylation (OXPHOS) defects and reactive oxygen species (ROS) production are attributed to mitochondrial dysfunction.
HMGB1 promotes mitochondrial transfer between hepatocellular …
网页2024年2月20日 · We found that RHOT1, a mitochondrial transport protein, promoted mitochondrial transfer and the migration and metastasis of HCC cells during this process. Under hypoxia, HMGB1 further regulated...
Mitochondrial Quality Control in Hepatocellular Carcinoma
网页2021年9月13日 · Quality control processes in mitochondria can repair or eliminate "unhealthy mitochondria" at the molecular, organelle, or cellular level and form an efficient integrated network that plays an important role in HCC tumorigenesis, patient survival, and tumor progression. Here, we review the influence …
Hypoxia regulates the mitochondrial activity of hepatocellular ...
网页2019年12月9日 · Using hepatocellular carcinoma (HCC) as a model, we revealed that the HIF-1 and the Notch signaling pathways cross-talk to control mitochondrial biogenesis of cancer cells to maintain...
MTFR2-dependent mitochondrial fission promotes HCC progression
网页2024年1月18日 · These genes play crucial roles in mitochondrial fission and have the potential to serve as important predictors and therapeutic targets for HCC. In conclusion, we developed a novel MTFR2-related prognostic signature comprising ten mitochondrial dynamics genes.
Cells | Free Full-Text | Mitochondrial Metabolic Signatures in ...
网页2021年7月27日 · Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. HCC progression and metastasis are closely related to altered mitochondrial metabolism, including mitochondrial stress responses, metabolic reprogramming, and mitoribosomal defects.
Deciphering a mitochondria-related signature to supervise …
网页2022年12月2日 · In this study, combined with 32 DEGs of mitochondria-related genes and 106 prognostic genes, we identified eight intersection genes for follow-up studies in HCC and normal tumors. Then, the six mitochondria-related gene signature was constructed for better forecasting the prognosis and immunity in the TCGA cohort.
An adenosine derivative promotes mitochondrial supercomplexes ...
网页2024年3月15日 · We propose that IFC-305 restores the mitochondrial bioenergetics in HCC by normalizing the quantity, morphology, and function of mitochondria, possibly as part of its hepatic restorative effect.
MTFR2-dependent mitochondrial fission promotes HCC progression
网页2024年1月18日 · The mitochondrial imbalance characterized by increased fission and upregulated MTFR2 and DNM1L expression was substantiated in both HCC specimens and cell lines. In conclusion, we developed a novel MTFR2-related prognostic signature comprising ten mitochondrial dynamics genes.