T cell responses to cytomegalovirus - Nature Reviews Immunology
网页2016年4月25日 · Clonal TCR analysis revealed little overlap between clones of HCMV-specific T CM cells (which are IL-7 receptor subunit-α (IL-7Rα) +) and T EM cells (which are IL-7Rα −).
Identification of HCMV-derived T cell epitopes in seropositive
网页2020年3月2日 · Multiple HCMV-directed specificities in the memory T cell pool of single individuals indicate that physiologic anti-HCMV T cell responses are directed against a broad range of antigens. Thus, the unbiased identification of naturally presented viral epitopes enabled a comprehensive and systematic assessment of the …
HCMV-specific T-cell therapy: do not forget supply of help
网页Human cytomegalovirus infections have a major negative effect on morbidity and mortality of immunosuppressed allograft recipients and indirectly on graft function and survival. The adoptive antiviral T-cell therapy is a novel therapeutic tool to restore immune competence after solid organ transplant ….
Identification of novel canonical and cryptic HCMV-specific T-cell ...
网页2024年1月30日 · Reactivation of latent human cytomegalovirus (HCMV) is the most common infectious complication after allogeneic stem cell transplantation (allo-SCT), resulting in high morbidity and mortality. 1, 2 Clinical evidence indicates that a delayed HCMV-specific T-cell response is a main risk factor of …
Transcriptional signature of durable effector T cells elicited by a ...
网页2024年4月1日 · We detected HCMV IE-1 and pp65 specific T cells in peripheral blood mononuclear cells (PBMCs) collected from V160 and placebo subjects at month 9, and included PBMCs from age- and...
Human Cytomegalovirus (HCMV)-Specific CD4+ T Cells Are …
网页2017年2月28日 · CD4 + T cells specific to the HCMV proteins studied were predominantly effector memory cells and produced both cytotoxic (CD107a expression) and cytokine (macrophage inflammatory protein 1β secretion) effector responses.
Pathogenesis of human cytomegalovirus in the …
网页2021年6月24日 · Gabanti, E. et al. Human cytomegalovirus (HCMV)-specific CD4 + and CD8 + T cells are both required for prevention of HCMV disease in seropositive solid-organ transplant recipients. PLoS...
Secretion of IFN-γ by specific T cells in HCMV infection - Cell Press
网页According to the HCMV infection status and immune response of allo-HSCT recipients, assessment of the relationship between HCMV infection and IFN-γ secreted by T cells specific to HCMV might provide a theoretical basis for evaluating the HCMV reactivation risk and the need for antiviral treatment after transplantation.
Identification of HCMV-derived T cell epitopes in seropositive ...
网页2020年3月2日 · In healthy individuals, immune control of persistent human cytomegalovirus (HCMV) infection is effectively mediated by virus-specific CD4 + and CD8 + T cells. However, identifying the repertoire of T cell specificities for HCMV is hampered by the immense protein coding capacity of this betaherpesvirus.
Engineered HCMV‐infected APCs enable the identification of new ...
网页2024年6月24日 · A11 SAL -specific T cells were also detectable in vivo in immunosuppressed transplant patients and shown to be effective in an in vitro HCMV-infection model, suggesting their crucial role in inhibiting viral replication and improvement of patient's outcome.
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