HSP90B1 - Wikipedia
Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that in humans is encoded by the HSP90B1 gene. [5] [6] HSP90B1 is an HSP90 paralogue that is found in the endoplasmic reticulum.
HSP90B1 Gene - GeneCards | ENPL Protein | ENPL Antibody
2024年10月2日 · HSP90B1 (Heat Shock Protein 90 Beta Family Member 1) is a Protein Coding gene. Diseases associated with HSP90B1 include Pelizaeus-Merzbacher-Like Disease and Platyspondylic Lethal Skeletal Dysplasia, Torrance Type. Among its related pathways are Unfolded Protein Response (UPR) and Cellular responses to stimuli.
疾病治疗新视角 | “冷门” 的热休克蛋白90 - 知乎
HSP90简介. 热休克蛋白共分为五类，HSP100、HSP90、HSP70、HSP60 以及小分子热休克蛋白 small Heat Shock Proteins (sHSPs)。. 作为今天的主角，HSP90 是人体中含量最丰富的蛋白之一，细胞内每百个蛋白中就有1-2个由 HSP90 构成。. 它也是细胞中必不可缺的分子伴侣蛋白之一 ...
Structural and functional complexity of HSP90 in cellular ... - Nature
2023年7月31日 · Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating proteostasis, long recognized for its function in protein folding and maturation. A view is...
HSP90B1 heat shock protein 90 beta family member 1 [ (human)]
This gene encodes a member of a family of adenosine triphosphate (ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum.
The HSP90 Family: Structure, Regulation, Function, and …
In humans, the gene encoding GRP94 is known as HSP90B1 and is located on chromosome 12. The regulation of GRP94 follows the same transcriptional regulation as in cytosolic HSP90. However, it is mainly induced by ER stress or overload rather than a simple heat shock.
Identification of HSP90B1 in pan-cancer hallmarks to aid
2024年1月20日 · In the present study, we employed multi-omics analyses and cohort validations to explore the dynamic expression of HSP90B1 in pan-cancer and comprehensively evaluate HSP90B1 as a novel biomarker that hold promise for precision cancer diagnostics and …
Unleashing the full potential of Hsp90 inhibitors as cancer ...
2020年1月20日 · Upon proteotoxic stress, Hsp90 binds to unfolded client proteins and dissociates HSF1 from HSP90, which in turn induces translocation of HSF1 to the nucleus and subsequent expression of heat shock...
The HSP90 chaperone machinery - Nature Reviews Molecular …
2017年4月21日 · Heat shock protein 90 (HSP90) is a molecular chaperone that is conserved from bacteria to humans and facilitates the maturation of substrates (or clients) that are...
Abstract. Heat shock proteins play crucial roles in various biochemical processes, encompassing protein folding and transloca-tion. HSP90B1, a conserved member of the heat shock protein family, growing evidences have demonstrated that it …