Clinical pathophysiology of hypoxic ischemic brain injury after …
2017年4月13日 · Hypoxic ischemic brain injury (HIBI) after cardiac arrest (CA) is a leading cause of mortality and long-term neurologic disability in survivors. The pathophysiology of HIBI encompasses a heterogeneous cascade that culminates in secondary brain injury and neuronal cell death. This begins with primary injury to the brain caused by the immediate cessation of cerebral blood flow following CA ...
Monitoring and modifying brain oxygenation in patients at risk of ...
2021年8月31日 · The cornerstone of hypoxic ischemic brain injury management has traditionally focused on preventing secondary ischemic injury, following the return of spontaneous circulation (ROSC) . Among the various mechanisms implicated in the pathophysiology of secondary injury, post-resuscitation cerebral ischemia is linked to central physiologic ...
Prognostication after cardiac arrest | Critical Care | Full Text
2018年6月5日 · Hypoxic–ischaemic brain injury (HIBI) is the main cause of death in patients who are comatose after resuscitation from cardiac arrest. A poor neurological outcome—defined as death from neurological cause, persistent vegetative state, or severe neurological disability—can be predicted in these patients by assessing the severity of HIBI. The most commonly used indicators of severe HIBI ...
Individualized perfusion targets in hypoxic ischemic brain injury …
2017年10月24日 · Secondary injury is a major determinant of outcome in hypoxic ischemic brain injury (HIBI) after cardiac arrest and may be mitigated by optimizing cerebral oxygen delivery (CDO2). CDO2 is determined by cerebral blood flow (CBF), which is dependent upon mean arterial pressure (MAP). In health, CBF remains constant over the MAP range through cerebral autoregulation. In HIBI, the zone of intact ...
Abnormal movements in critical care patients with brain injury: a ...
2016年3月14日 · Vascular brain injuries: acute ischemic stroke, ICH and SAH. Cerebrovascular events are frequently encountered in the ICU, and a wide variety of abnormal movements may result from the primary vascular injury or secondary injury that often follows due to edema, mass effect and disruption of the brain circuits [9, 15, 16, 38].
How to assess prognosis after cardiac arrest and therapeutic ...
2014年1月14日 · Regional (that is, the occipital and temporal lobes), spatial (that is, widespread and diffuse lesions) or temporal (that is, absence of resolution in FLAIR abnormalities) MRI findings may provide better insight into the degree and mechanisms of hypoxic–ischemic brain injury, and hence better predict outcome in comatose survivors, including ...
Low b-value diffusion weighted imaging is promising in the …
2018年6月20日 · Background Cardiorespiratory arrest can result in a spectrum of hypoxic ischemic brain injury leading to global hypoperfusion and brain death (BD). Because up to 40% of patients with BD are viable organ donors, avoiding delayed diagnosis of this condition is critical. High b-value diffusion weighted imaging (DWI) measures primarily molecular self-diffusion; however, low b-values are sensitive ...
Respiratory challenges and ventilatory management in different …
2023年6月23日 · ABI is heterogeneous and covers different subtypes, notably traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial bleeding and hypoxic ischemic brain injury. Since the brain is surrounded by the inextensible skull, any change affecting brain volume would result in an increase in intracranial pressure (ICP) and impairment of ...
Association of ultra-early diffusion-weighted magnetic resonance ...
2023年1月13日 · Muttikkal TJ, Wintermark M. MRI patterns of global hypoxic-ischemic injury in adults. J Neuroradiol. 2013;40(3):164–71. Article Google Scholar Pai V, Sitoh YY, Purohit B. Gyriform restricted diffusion in adults: Looking beyond thrombo-occlusions. Insights Imaging. 2020;11(1):20. Article Google Scholar
Neuroprotection in acute brain injury: an up-to-date review
2015年12月1日 · Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms ...