Interleukin 15 - Wikipedia
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to …
Interleukin 15: A key cytokine for immunotherapy - PubMed
Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic potential. It is predominantly expressed by the myeloid cells, as well as other …
Interleukin - StatPearls - NCBI Bookshelf - National Center for ...
2022年8月22日 · Interleukin-15 (IL-15) Monocytes, epithelium, and muscles make IL-15. It acts on T cells and activated B cells. It causes the proliferation of both B and T cells. It causes NK cell …
Interleukin 15 - an overview | ScienceDirect Topics
Interleukin (IL)-15 is a ubiquitously expressed cytokine existing in both intracellular and secretory forms. Here we review the expression, regulation, and functions of IL15 and its receptors in …
Interleukin 15: biology and relevance to human disease
2001年1月1日 · Studies to date examining the biology of IL-15 have identified several key nonredundant roles, such as IL-15's importance during natural killer (NK) cell, NK–T cell, and …
Interleukin 15: its role in inflammation and immunity - PubMed
Interleukin 15 (IL-15) is a 14-15 kDa polypeptide that belongs to the 4 alpha-helix-bundle family of cytokines and was originally discovered due to its T cell proliferative activity. It utilizes the …
Discovery of a novel IL-15 based protein with improved ... - Nature
2018年5月16日 · Interleukin-15 (IL-15) can promote both innate and adaptive immune reactions by stimulating CD8 + /CD4 + T cells and natural killer cells (NK) while showing no effect in …
IL-15/IL-15 receptor biology: a guided tour through an expanding ...
The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a …
Interleukin-15 and cancer: some solved and many unsolved …
Soluble interleukin (IL)-15 exists under two forms: as monomer (sIL-15) or as heterodimeric complex in association with sIL-15Rα (sIL-15/IL-15Rα). Both forms have been successfully …
The biology of interleukin-2 and interleukin-15: implications for ...
2006年8月1日 · Interleukin-2 and interleukin-15 have pivotal roles in the control of the life and death of lymphocytes. Although their heterotrimeric receptors have two receptor subunits in...