Interleukin 12 - Wikipedia
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, [1] macrophages, neutrophils, helper T cells and human B- lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12.
Interleukin-12 and the regulation of innate resistance and …
Feb 1, 2003 · Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that regulates T-cell and natural killer-cell responses, induces the production of interferon-γ (IFN-γ), favours the...
Interleukin-12: an update on its immunological activities, …
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of the p35 and p40 subunits. It is produced by antigen-presenting cells and plays a critical role in host defense against intracellular microbial infection and control of malignancy via its ability to stimulate both innate and adaptive immune effector cells.
Interleukin-12: a proinflammatory cytokine with …
Interleukin-12 (IL-12) is a heterodimeric cytokine produced mostly by phagocytic cells in response to bacteria, bacterial products, and intracellular parasites, and to some degree by B lymphocytes. IL-12 induces cytokine production, primarily of IFN …
Interleukin 12 (IL-12) Family Cytokines: Role in Immune Pathogenesis ...
Interleukin 12 (IL-12) family is comprised of 4 members, IL-12, IL-23, IL-27 and IL-35. IL-12, IL-23 and IL-27 are secreted by activated antigen presenting cells (APC) during antigen presentation to naïve T cells while IL-35 is a product of regulatory T and B cells [1–3].
IL-12 family cytokines: immunological playmakers - Nature
Jul 19, 2012 · Among the vast array of bioactive cytokines, the interleukin 12 (IL-12) family is unique. This is the only family of heterodimeric cytokines, which endows them with several unique and...
The Immunobiology of the Interleukin-12 Family: Room for …
The IL-12 family of cytokines influences the outcome of cancer, infection, and inflammatory diseases. Stumhofer, Hunter, and Tait review the combinatorial biology inherent to this family and the recent clinical insights that underscore the critical role of these pathways in human disease.
Interleukin 12 - an overview | ScienceDirect Topics
Interleukin 12 (IL-12), a cytokine that stimulates T-helper anti-tumor immune responses, could prove beneficial as a therapy in treating cancer. However, the systemic administration of IL-12 might cause serious health side effects.
Interleukin-12: Functional activities and implications for disease
Interleukin-12 (IL-12) was the first member of the IL-12 family of cytokines to be identified and has therefore become its eponym. It is a heterodimeric protein of two subunits (p35, p40) secreted by phagocytic cells in response to pathogens and mainly acts through STAT4 to …
Interleukin-12: Biological Properties and Clinical Application
Aug 15, 2007 · Interleukin-12 (IL-12) is a heterodimeric protein, first recovered from EBV-transformed B cell lines. It is a multifunctional cytokine, the properties of which bridge innate and adaptive immunity, acting as a key regulator of cell-mediated immune responses through the induction of T helper 1 differentiation.