DEAD-box RNA helicase subunits of the Drosha complex are
Apr 15, 2007 · Small interfering RNA (siRNA) oligonucleotides of p68, p72 and Drosha were used for knockdown of endogenous protein expression using siGENOME (Dharmacon, Lafayette, …
Structure of Human DROSHA - ScienceDirect
Jan 14, 2016 · MicroRNA maturation is initiated by RNase III DROSHA that cleaves the stem loop of primary microRNA. DROSHA functions together with its cofactor DGCR8 in a heterotrimeric …
Emerging roles of DROSHA beyond primary microRNA processing
DROSHA is the catalytic subunit of the Microprocessor complex, which initiates microRNA (miRNA) maturation in the nucleus by recognizing and cleaving hairpin precursors embedded …
Drosha - Wikipedia
Drosha is a Class 2 ribonuclease III enzyme [5] that in humans is encoded by the DROSHA (formerly RNASEN) gene. [6] [7] [8] It is the primary nuclease that executes the initiation step …
Drosha drives the formation of DNA:RNA hybrids around DNA
Feb 7, 2018 · Drosha is required within minutes of break induction, suggesting a central and early role for RNA processing in DNA repair. Sequencing of DNA:RNA hybrids reveals RNA …
生命学院王宏伟和生物物理研究所许瑞明课题组合作在《分子细胞 …
该结构证实了Drosha在切割位点界定中的决定性作用，并首次明确了PAZ、MB helix、以及dsRBD结构域分别对pri-miRNA的相应区域进行识别，协同完成切割位点的定位。
Structure of Human DROSHA - Cell Press
Jan 14, 2016 · The heretofore-elusive structure of DROSHA provides insights into how nascent microRNAs are recognized and cleaved in their initial processing step and reveals an …
RNase III nucleases from diverse kingdoms serve as antiviral ... - Nature
Jun 28, 2017 · Here we demonstrate that Drosha and related RNase III ribonucleases from all three domains of life also elicit a unique RNA-targeting antiviral activity.
Jan 14, 2016 · DROSHA functions together with its cofactor DGCR8 in a heterotrimeric complex known as Microprocessor. Here, we report the X-ray struc-ture of DROSHA in complex with …
human genome encodes only two RNase III proteins: Drosha and Dicer. Whereas Dicer homologs are found in a broad range of eukaryotic organisms, Drosha homologs are present only in …