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ATP-sensitive potassium channel - Wikipedia
ATP-sensitive potassium channel (K ATP channel) is a type of potassium channel that is gated by intracellular nucleotides, ATP and ADP. Learn about its discovery, structure, regulation, and functions in different tissues and cells.
ATP敏感钾通道 - 百度百科
ATP敏感性钾通道（ATP-sensitive potassium channel，KATP）于1983年由Noma首先在豚鼠的 心肌细胞 上发现，其特征是通道活性随胞内ATP浓度升高而被显著抑制。 KATP通道现已证明多种 组织细胞 包括人的心肌细胞存在该通道，尤其在 心肌缺血 、 室性心动过速 、心衰的情况下，是重要的心脏保护因子，对于指导临床药物治疗、靶点的选择上具有重要的指导价值。 中文名. ATP敏感钾通道. 外文名. ATP-sensitive potassium channel，KATP. 所属学科. 生物. 目录. 1 分布. 2 …
Structural insights into the mechanism of pancreatic KATP channel ...
2022年5月19日 · ATP-sensitive potassium channels (KATP) are metabolic sensors that convert the intracellular ATP/ADP ratio to the excitability of cells. They are involved in many...
KATP channels as molecular sensors of cellular metabolism | Nature
2006年3月22日 · In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel activity provides a unique link between cellular energetics and electrical excitability.
KATP Channels and Cardiovascular Disease | Circulation Research
2013年3月29日 · ATP-sensitive potassium (KATP) channels were first discovered in the heart 30 years ago. Reconstitution of KATP channel activity by coexpression of members of the pore-forming inward rectifier gene...
The role of KATP channels in cerebral ischemic stroke and …
2018年4月19日 · KATP channels play important roles in controlling and regulating cellular functions in response to metabolic state, which are inhibited by ATP and activated by Mg-ADP, allowing the cell to couple...
Functional dissection of KATP channel structures reveals the …
2024年2月1日 · ATP-sensitive potassium (KATP) channels are metabolic sensors on the plasma membrane. Their activities are inhibited by intracellular ATP and activated by intracellular Mg-ADP.
The Pharmacology of ATP-Sensitive K+ Channels (KATP)
2021年7月11日 · ATP-sensitive K+ channels (KATP) are inwardly-rectifying potassium channels, broadly expressed throughout the body. KATP is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels thus playing an important...
New insights into KATP channel gene mutations and neonatal ... - Nature
2020年5月6日 · ATP-sensitive potassium channels (K ATP channels) regulate insulin secretion from pancreatic β-cells by closing in response to metabolically generated ATP. Gain-of-function mutations in the genes...