Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, …
2021年6月28日 · Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital …
核酸脂质纳米粒（LNP）科普 —— 组成成分及作用 - 知乎
2021年8月25日 · 核酸脂质纳米粒（LNP）科普 —— 组成成分及作用 基因治疗（gene therapy）是通过将外源基因导入靶细胞，以纠正或补偿缺陷、异常基因引起的疾病，达到治疗目的的一种 …
The 60-year evolution of lipid nanoparticles for nucleic acid
2024年7月4日 · The development of LNP technology for nucleic acid delivery is based on insights gained from basic studies on the physical properties and functional roles of lipids in …
Comprehensive analysis of lipid nanoparticle formulation and ...
Lipid nanoparticles (LNPs) are promising delivery carriers that provide RNA stability, with strong transfection efficiency, favorable and tailorable pharmacokinetics, limited toxicity, and …
The role of lipid components in lipid nanoparticles for vaccines …
2022年9月1日 · Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In addition, many preclinical and clinical studies, including the siRNA-LNP product, …
Lipid nanoparticles for mRNA delivery | Nature Reviews Materials
2021年8月10日 · After intramuscular injection, lipid nanoparticle–mRNA (LNP–mRNA) vaccines are internalized by somatic cells (for example, muscle cells) and tissue-resident or recruited …
A careful look at lipid nanoparticle characterization ... - Nature
2024年1月29日 · LNPs are synthesized via coassembly, often rapid solvent mixing, of five distinct components: ionizable (cationic) lipid, helper phospholipid, polyethylene glycol (PEG)-lipid, …
Lipid Nanoparticles─From Liposomes to mRNA Vaccine …
2021年11月23日 · Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital …
Design of lipid-based nanoparticles for delivery of therapeutic …
2023年3月1日 · Among the diversity of formulations based on nanocomplexes, lipid-based nanoparticles (LNPs) represent the most advanced platform for systemic delivery [15]. This …
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their ...
2023年9月1日 · LNP formulations typically include ionizable lipids, phospholipids, cholesterol, and PEG-lipids, each of which plays a pivotal role in the function of LNPs (Fig. 1). First, …
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