LRP1 - Wikipedia
网页Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis.
LRP1 Gene - GeneCards | LRP1 Protein | LRP1 Antibody
网页2024年8月6日 · LRP1 (LDL Receptor Related Protein 1) is a Protein Coding gene. Diseases associated with LRP1 include Keratosis Pilaris Atrophicans and Developmental Dysplasia Of The Hip 3. Among its related pathways are Visual phototransduction and Statin inhibition of cholesterol production.
Nature：神经退行性疾病治疗下一个新靶点——LRP1 - 知乎
网页4月1日，在 Nature 上发表的一篇论文中，Kosik教授和他的团队揭示了tau蛋白在神经元之间的一种扩散机制：低密度脂蛋白受体相关蛋白1 (low-denisity lipoprotein receptor-related protein 1， LRP1)作为这一过程的主要参与者，可以控制tau蛋白的内吞及其在神经元之间的 …
LRP1 is a master regulator of tau uptake and spread - Nature
网页2020年4月1日 · Our results identify LRP1 as a key regulator of tau spread in the brain, and therefore a potential target for the treatment of diseases that involve tau spread and aggregation.
Low-density lipoprotein receptor-related protein 1 (LRP1) is a …
网页2021年6月24日 · Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue. Jie Qu, Sarah Fourman, Maureen...
LRP1 LDL receptor related protein 1 [ (human)] - National Center …
网页LRP1 mediates anti-apoptotic function in neurons by regulating insulin receptor and the Akt survival pathway; LRP1 exerts remarkable effects to retain the mature phenotype of chondrocytes as a critical mediator of cell signaling.
LDL receptor-related protein 1 (LRP1), a novel target for ... - Nature
网页2022年6月10日 · Here, we report the finding of a novel receptor, low-density lipoprotein receptor-related protein 1 (LRP1), that is expressed on the BLB, as a potential target for shuttling therapeutics across...
Role of LRP1 in the pathogenesis of Alzheimer's disease ... - PubMed
网页Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP)1 in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the most studied by genetic, neuropathological, and biomarker analyses (clinical studies) or cellular and animal model systems ( ….
LRP1 and its interacting partners in tissue homeostasis
网页2021年10月10日 · LRP1 sustains pulmonary function and modulates the inflammatory response in lung disease. LRP1 is abundantly expressed in smooth muscle cells. Earlier studies showed that LRP1 interacts with PDGF- and TGF-receptors to reduce smooth muscle cell proliferation and migration in protection against …
Multi-faceted role of LRP1 in the immune system - PMC
网页2023年3月20日 · This review is an attempt to describe a very well-known receptor in lipoprotein studies – the low-density lipoprotein receptor related protein 1 (LRP1) - in a new light, as a potential therapeutic target for GVHD prevention and treatment.