Langerhans cell - Wikipedia
Langerhans cells derive from primitive erythro-myeloid progenitors that arise in the yolk sac outside the embryo in the first trimester of pregnancy, and under normal circumstances persist throughout life, being replenished by local proliferation as necessary.
Langerhans Cell Histiocytosis Treatment - NCI - National Cancer Institute
2024年6月6日 · Langerhans cell histiocytosis (LCH) is a rare disease that begins in LCH cells. LCH cells are a type of dendritic cell that normally helps the body fight infection. Sometimes mutations (changes) develop in genes that control how dendritic cells function. These include mutations of the BRAF, MAP2K1, RAS, and ARAF genes.
朗格汉斯细胞 - 维基百科，自由的百科全书
蘭格漢氏細胞 （英語： Langerhans cell，又稱蘭氏細胞）是在 皮膚 和 黏膜 的 樹狀細胞 （抗原呈递细胞），其中含有稱作 伯贝克颗粒 （英语：Birbeck granules） 的 胞器，在上皮中的任何一層都有蘭格漢氏細胞，不過主要是在 棘狀層 中 [1]，此類細胞也會出現在血管周圍的乳狀真皮中 [1]，也會在 口腔黏膜 （英语：oral mucosa） 、 包皮 及 阴道上皮 中 [2]。 蘭格漢氏細胞也會出現在其他組織中，例如若有罹患 蘭格罕細胞組織球增生症 （英语：Langerhans cell …
朗格汉斯细胞 - 百度百科
朗格汉斯细胞（Langerhans cell，LCs）是一种来源于骨髓的 免疫活性细胞，是具有特殊免疫刺激能力的 抗原呈递细胞，具有很强的识别意识，摄取和呈递 外源性抗原 的功能，在人体的防御系统中起着极为重要的作用 [1]。 朗格汉斯细胞是表皮唯一的抗原提呈细胞，在接受抗原刺激后表皮LCs向引流淋巴结迁移，活化T淋巴细胞发挥免疫效应 [2]。 在胚胎期经血液移居并终身聚居在特定组织内，如：复层鳞状上皮，包括表皮， 皮肤附属器，口腔粘膜，食管等，也存在于淋巴样 …
Langerhans Cell - Biology Dictionary
2021年4月26日 · Langerhans cells are a type of immune cell found primarily in the epidermis that have important roles in the stimulation and suppression of the adaptive immune response. They are members of the dendritic cell family and function as antigen-presenting cells.
Langerhans cell histiocytosis | About the Disease | GARD
Currently, GARD aims to provide the following information for this disease: Population Estimate:Fewer than 50,000 people in the U.S. have thisdisease. Symptoms:May start to appear at any time in life. Organizations:Patient organizations are available to help find a specialist, or advocacy and support for this specific disease.
Langerhans cell histiocytosis - MedlinePlus
Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. Langerhans cells, which help regulate the immune system, are normally found throughout the body, especially in the skin, lymph nodes, spleen, lungs, liver, and bone marrow.
Langerhans Cell Histiocytosis Treatment (PDQ®) - NCI
Histiocytic diseases in children and adults are caused by an abnormal accumulation of cells of the mononuclear phagocytic system. This summary discusses only Langerhans cell histiocytosis (LCH), a myeloid-derived dendritic cell disorder.
Origin, homeostasis and function of Langerhans cells and other …
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and...
Langerhans cell histiocytosis | Blood - American Society of …
2020年4月16日 · Langerhans cell histiocytosis (LCH) is a disease characterized by clonal expansion of myeloid precursors that differentiate into CD1a + /CD207 + in lesions. It presents at all ages with various degrees of systemic involvement, and although cure rates are high, severe long-term neurological or endocrine complications may affect quality of life.