A syngeneic MC38 orthotopic mouse model of colorectal cancer …
2022年9月28日 · While CT26 cells have been orthotopically implanted with high fidelity, successful engraftment of orthotopic MC38 tumors varies greatly between studies. Thus, we have developed a detailed protocol for MC38 orthotopic tumor inoculation via intracecal injection.
Different syngeneic tumors show distinctive intrinsic tumor …
2022年2月28日 · MC38 tumors were engrafted into these 4 strains of DTR-knock-in (DTR-KI) mice along with the wild-type (naïve) mice, followed by the DT treatment, and monitored for the depletion of specific...
syngeneic MC38 orthotopic mouse model of colorectal cancer …
2022年9月28日 · Utilization of a syngeneic mouse model allows for a complete immune landscape, key for adaptive immunotherapy studies. MC38 and CT26 cells are commonly used murine colorectal cancer cell lines with clinically relevant mutations.
Targeting immune checkpoints potentiates immunoediting and
2018年1月2日 · In our mouse model used to recapitulate the process of cancer immunoediting, MC38 cells were subcutaneously injected into wild-type C57Bl/6 and immunodeficient RAG1 −/− mice.
MC38 Syngeneic Mouse Model - Altogen Labs
The MC38 tumorigenic epithelial cell line is isolated from mice with colon adenocarcinoma and expresses high levels of human carcinoembryonic antigen (CEA) and has been used across many research studies.
Syngeneic Mouse Models | Charles River - Charles River …
MC38 mouse model, also known by various synonyms such as MC-38, MCA-38, and Mouse Colon 38, is derived from a colon tumor in a C57BL/6 mouse, its primary advantage being its sensitivity towards anti-PD1 and CTLA4 treatment.
Targeting immune checkpoints potentiates immunoediting and …
We first characterize the genomic and transcriptomic landscape of the mouse colon adenocarcinoma cell line MC38 (mouse colon #38) that was induced by the subcutaneous injection of dimethylhydrazine in C57Bl/6 mice 13, and show that this cell line is a valid model for hypermutated/MSI CRC.
(PDF) A syngeneic MC38 orthotopic mouse model of
2022年9月28日 · Utilization of a syngeneic mouse model allows for a complete immune landscape, key for adaptive immunotherapy studies. MC38 and CT26 cells are commonly used murine colorectal cancer cell...
A syngeneic MC38 orthotopic mouse model of ... - Vanderbilt …
Utilization of a syngeneic mouse model allows for a complete immune landscape, key for adaptive immunotherapy studies. MC38 and CT26 cells are commonly used murine colorectal cancer cell lines with clinically relevant mutations.
Abstract 1562: Syngeneic MC38 mouse colorectal tumor model: …
2021年7月1日 · One such model is the MC38 murine CRC cell line, derived from a grade-III adenocarcinoma chemically induced in a female C57BL/6 mouse. The aim of this study was to analyze the immune infiltration in subcutaneous MC38 tumors and …