Metabolic Adaptation in Methicillin-Resistant Staphylococcus …
2018年11月27日 · Using genomic, metabolic, and gene expression studies, we demonstrate that host-adapted MRSA undergoes substantial metabolic reprogramming, allowing for the use of available carbon sources to simultaneously promote …
Metabolic Adaptation in Methicillin-Resistant Staphylococcus …
We investigated how MRSA adapts to the human airway to establish chronic infection, as occurs during cystic fibrosis (CF). MRSA isolates from patients with CF that were collected over a 4-year period were analyzed by whole-genome sequencing, transcriptional analysis, …
Methicillin-resistant Staphylococcus aureus : an overview of
2019年2月8日 · Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen both within hospitals and in the community. In this Review, Fowler and colleagues provide an...
Mechanisms of Methicillin Resistance in Staphylococcus ...
Methicillin-resistant S. aureus (MRSA) poses a significant and enduring problem to the treatment of infection by such strains. Resistance is usually conferred by the acquisition of a nonnative gene encoding a penicillin-bindin ….
Adaptive Metabolism of Staphylococcus aureus Revealed by ...
2022年1月19日 · These metabolites were mapped to relevant metabolic pathways to elucidate the adaptive metabolic processes of both methicillin-sensitive SA (MSSA) and methicillin-resistant SA (MRSA). We also detected an increased expression of virulence genes agr-I and sea of MRSA supplemented with both glucose and dextrin by qPCR.
Two codependent routes lead to high-level MRSA - PubMed
2024年10月31日 · Methicillin-resistant Staphylococcus aureus (MRSA), in which acquisition of mecA [which encodes the cell wall peptidoglycan biosynthesis component penicillin-binding protein 2a (PBP2a)] confers resistance to β-lactam antibiotics, is of major clinical concern. We show that, in the presence of antibiotics, MRSA adopts an alternative mode of cell division and shows an altered peptidoglycan ...
Comparative metabolomics revealing Staphylococcus aureus metabolic …
2017年8月16日 · Here, we utilized a mass spectrometry‐based targeted metabolic profiling technique to characterize the metabolome of a pair of isogenic methicillin‐susceptible and resistant Staphylococcus aureus ( MSSA and MRSA) strains RN 450 and 450M treated with the sublethal dose of three antibiotics from different classes (β‐lactams, aminoglycosides and qu...
Intracellular Staphylococcus aureus Modulates Host ...
2018年8月8日 · MRSA intracellular infection leads to extensive metabolic rerouting leading to the host exhibiting signs of metabolic starvation. In this study, we were interested in the metabolic changes brought about by intracellular infection of nonphagocytic cells.
GltS regulates biofilm formation in methicillin-resistant ...
2022年11月23日 · Methicillin-resistant Staphylococcus aureus (MRSA) is a leading nosocomial pathogen and commonly associated with significant morbidity, hospital mortality, length of stay,...
RNase III CLASH in MRSA uncovers sRNA regulatory ... - Nature
2022年6月22日 · We propose that RsaE acts to couple metabolic pathways to virulence through post-transcriptional regulation of its target mRNAs. RNAIII is required for optimal esxA toxin production