Marker aided introgression of ‘Saltol’, a major QTL for ... - Nature
2020年9月4日 · Among the BC 3 F 4 near isogenic lines (NILs) developed, recurrent parent genome recovery ranged from 96.67 to 98.57%. Multi-season evaluation identified some of the NILs showing significantly...
Microsatellite instability: A 2024 update - Wiley Online Library
2024年3月25日 · Deficient mismatch repair (dMMR) results in microsatellite instability (MSI), a pronounced mutator phenotype. High-frequency MSI (MSI-H)/dMMR is gaining increasing interest as a biomarker for advanced cancer patients to determine their eligibility for …
Microsatellite instability: a review of what the oncologist should …
2020年1月13日 · The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) tumors recently have been reported that can benefit from immunotherapy, and MSI can be used as a genetic instability of a tumor detection index.
Genetic diversity of tumors with mismatch repair deficiency ... - AAAS
2019年5月3日 · Defects in DNA mismatch repair prevent tumors from repairing certain types of DNA damage and lead to a hypermutable genomic state known as microsatellite instability (MSI). Some tumors with a high degree of MSI may be treatable with PD-1 (programmed cell death–1) immunotherapy, but patient response is highly variable.
Pathology Outlines - Microsatellite instability pathway
2020年4月28日 · Microsatellite instability (MSI) is one of the pathways implicated in colorectal adenocarcinoma (CRC) carcinogenesis; colorectal cancer with MSI is referred to as MSI / microsatellite unstable or MMR deficient (dMMR) colorectal cancer
ESMO recommendations on microsatellite instability testing for ...
MSI/dMMR can be identified using immunohistochemistry to detect loss of MMR proteins and/or molecular tests to show microsatellite alterations. Together with tumour mutational burden (TMB) and PD-1/PD-L1 expression, it plays a role as a predictive biomarker for immunotherapy.
A molecular portrait of microsatellite instability across multiple ...
2017年6月6日 · Microsatellite instability (MSI) refers to the hypermutability of short repetitive sequences in the genome caused by impaired DNA mismatch repair. Although MSI...
Among the BC3f4 near isogenic lines (NILs) developed, recurrent parent genome recovery ranged from 96.67 to 98.57%. Multi-season evaluation identified some of the NILs showing significantly...
Mismatch Repair and Microsatellite Instability Testing for Immune ...
2023年1月5日 · What are the diagnostic test characteristics of MMR-IHC, PCR-based MSI analysis, and NGS-based MSI analysis when predicting germline Lynch mutations? The target population for the CAP guideline is patients with cancer who are being tested for DNA MMR to determine appropriate therapy with immune checkpoint inhibitors.
Landscape of Microsatellite Instability Across 39 Cancer Types
2017年10月3日 · Microsatellite instability (MSI) is a pattern of hypermutation that occurs at genomic microsatellites and is caused by defects in the mismatch repair system. Mismatch repair deficiency that leads to MSI has been well described in several types of human cancer, most frequently in colorectal, endometrial, and gastric adenocarcinomas.