Differential methylation of enhancer at IGF2 is associated with ...
2019年5月3日 · In mice, Igf2 enhancer deletion disrupts the levels of TH protein and striatal dopamine, and induces transcriptional and proteomic abnormalities affecting neuronal structure and...
Mouse frontal cortex mediates additive multisensory decisions
2023年6月8日 · Here, we show that mouse frontal cortex combines auditory and visual evidence; that this combination is additive, mirroring behavior; and that it evolves with learning. We trained mice in an audiovisual localization task.
Multimodal profiling of the transcriptional regulatory landscape of …
2022年2月7日 · Here, to systematically map the regulatory landscape of neural differentiation in the mouse neocortex, we profiled gene expression and chromatin accessibility in single cells and integrated these...
Functional enhancer elements drive subclass-selective expression …
We tested five PVALB enhancer-AAV vectors using intraparenchymal injections into the occipital cortex in macaque monkeys and obtained strong evidence for conservation of cell-subclass-specific expression from mouse to monkey.
Orbitofrontal control of visual cortex gain promotes visual …
2020年6月3日 · Activating the projections from cingulate region of the frontal cortex to V1 enhances and suppresses V1 responses for the sites near and surround axonal activation, respectively, consistent...
Local and long-range input balance: A framework for ... - Science
2024年9月18日 · To most effectively highlight how the development of local and long-range inputs relates to behavior function, this review will use research on mouse frontal-visual cortical neurons projecting from anterior cingulate area (ACA) to visual cortex as an example circuit.
Differential methylation of enhancer at IGF2 is associated with ...
2019年5月3日 · In mice, Igf2 enhancer deletion disrupts the levels of TH protein and striatal dopamine, and induces transcriptional and proteomic abnormalities affecting neuronal structure and signaling. Our data suggests that epigenetic activation of the enhancer at IGF2 may enhance dopamine synthesis associated with major psychosis.
Cell type-specific chromatin accessibility analysis in the mouse …
2021年3月29日 · For this study, we assessed the frontal cortex of adult male mice, using two biological replicates for each condition. We included male mice only to avoid the confounding biological effect of sex and oestrous cycle on chromatin organization [6].
Mouse frontal cortex mediates additive multisensory decisions
2021年5月23日 · Here we show that to localize a stimulus mice combine auditory and visual spatial cues additively, a computation supported by unisensory processing in auditory and visual cortex and additive multisensory integration in frontal cortex.
Post-error recruitment of frontal sensory cortical projections …
Norman et. al found that behavioral errors recruit frontal sensory projections in mice. 30-Hz optogenetic stimulation of this pathway modulates performance following errors in behaving mice and recapitulates neurophysiological hallmarks of attention in anesthetized mice.