The MurG glycosyltransferase provides an oligomeric scaffold …
网页2019年3月15日 · MurG form oligomers with different stoichiometries. MurG is a peripheral membrane protein that interacts with phospholipids of the cytoplasmic membrane 17,19,20.
Peptidoglycan biosynthesis is driven by lipid transfer along …
网页2022年4月27日 · Next in function to MraY in the PG biosynthetic pathway is MurG, a peripheral protein on the inner leaflet of the cytosolic membrane that transfers a GlcNAc molecule to lipid I to form lipid II.
A comprehensive computational study to explore promising …
网页2024年3月26日 · The mechanism of peptidoglycan biosynthesis involves the main synthesizing enzyme glycosyltransferase MurG, which is known as a potential target for antibiotic therapy. Many MurG...
The essential peptidoglycan glycosyltransferase MurG forms a …
网页MurG is an essential glycosyltransferase catalysing the last intracellular step of peptidoglycan synthesis. To elucidate its role during elongation and division events, localization of MurG using immunofluorescence microscopy was performed.
Prioritization of Mur family drug targets against
网页2020年7月28日 · Based on the results of intra-comparative protein sequence analysis and enzymatic classification, we have chosen MurB, MurE, and MurG as the prioritized drug targets from A. baumannii and subjected them for …
The MurG glycosyltransferase provides an oligomeric scaffold for …
网页2019年3月15日 · Here, we explored this genetic arrangement in the human pathogen Bordetella pertussis and show that MurE and MurF are expressed as a single, bifunctional protein. EM, small angle X-ray scattering (SAXS), and analytical centrifugation (AUC) revealed that the MurE-MurF fusion displays an elongated, flexible …
E. Coli MurG: a paradigm for a superfamily of glycosyltransferases
网页MurG is an essential bacterial glycosyltransferase that is involved in the biosynthesis of peptidoglycan. The enzyme is found in all organisms that synthesize peptidoglycan and is a target for the design of new antibiotics. A direct assay to study MurG was reported recently, followed shortly by the crystal structure of E. coli MurG.
The essential peptidoglycan glycosyltransferase MurG forms a …
网页Summary In Escherichia coli many enzymes including MurG are directly involved in the synthesis and assembly of peptidoglycan. MurG is an essential glycosyltransferase catalysing the last intracellu...
网页MurG were further performed in strain LMC510, which contains the ftsI2158 that expresses a PBP3(Ts) protein. PBP3 is involved in peptidoglycan synthesis and localizes
Putative hexameric glycosyltransferase functional unit revealed …
网页2021年4月7日 · In this study, MurG from Acinetobacter baumannii (abMurG), a human pathogen, was characterized and its hexameric crystal structure was unveiled; this is the first homo-oligomeric structure to be described in the MurG family and the Mur family.