Cancer snap-shots: Biochemistry and glycopathology of O-glycans…
2024年3月1日 · O-glycans linked to proteins are subjected to change both qualitatively and quantitatively in cancer. • Some O-glycans (Lewis and sialyl Lewis antigens) can drive metastasis of primary tumors and spread to vital organs. • Information on stage specific glycans/glycoproteins is close to nothing in cancer. •
Glycosylation Changes in Cancer - Essentials of Glycobiology
Truncated O-GalNAc glycans Tn, STn, and T (Figure 47.2) are good markers for the detection of cancer in tumor sections. Furthermore, the detection of specific glycoproteins bearing these truncated O-glycans, such as cancer-specific MUC16 glycoforms, enhances the specificity of diagnosis and monitoring of cancer.
Glycosylation in cancer: mechanisms and clinical implications
2015年8月20日 · O-GlcNAc modifications have been implicated in key molecular events occurring in cancer, such as tumour cell proliferation (by regulating the activities of transcription factor forkhead box ...
Simple Sugars to Complex Disease—Mucin-Type O-Glycans in Cancer
This chapter describes mucin-type O-glycan biosynthesis, altered mucin-type O-glycans in primary tumors, including mechanisms for structural changes and contributions to the tumor phenotype, and clinical approaches to detect and target altered O-glycans for cancer treatment and management.
The role of O-glycosylation in human disease - ScienceDirect
2021年6月1日 · In the field of precision oncology, the acknowledgement of aberrant glycosylation features as critical elements of a tumor's intricate molecular landscape has highlighted the potential of cancer-derived O-glycan signatures as tumor-specific therapeutic targets, as well as biomarkers for patient stratification, clinical outcome and therapeutic ...
Cancer snap-shots: Biochemistry and glycopathology of O-glycans…
Glycans that are covalently linked to the polypeptide backbone of a protein through nitrogen or oxygen, are known as N-glycans or O-glycans, respectively. Although the role of glycans in the expression, physiology, and communication of cells is well documented, the function of these glycans in tumor biology is not fully elucidated.
Glycans as Targets for Drug Delivery in Cancer - PMC
2022年2月12日 · Alterations in glycosylation are frequently observed in cancer cells. Different strategies have been proposed to increase drug delivery to the tumor site in order to improve the therapeutic efficacy of anti-cancer drugs and avoid collateral cytotoxicity.
Mapping of truncated O-glycans in cancers of epithelial and non ...
2021年9月15日 · Novel immunotherapies targeting cancer-associated truncated O-glycans Tn (GalNAcα-Ser/Thr) and STn (Neu5Acα2–6GalNacα-Ser/Thr) are promising strategies for cancer treatment. However, no...
Display of the human mucinome with defined O-glycans by gene ... - Nature
2021年7月1日 · The normal core3 O-glycosylation pathway is downregulated in colorectal cancer 83, and truncated O-glycans including STn are found in colitis and other bowel inflammatory diseases 84.
Simple Sugars to Complex Disease—Mucin-Type O-Glycans in Cancer
2015年1月1日 · This chapter describes mucin-type O-glycan biosynthesis, altered mucin-type O-glycans in primary tumors, including mechanisms for structural changes and contributions to the tumor phenotype, and clinical approaches to detect and target altered O-glycans for cancer treatment and management.
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