CAR T cell killing requires the IFNγR pathway in solid but ... - Nature
2022年4月13日 · We found that the loss of genes in the interferon-γ receptor (IFNγR) signalling pathway (IFNGR1, JAK1 or JAK2) rendered glioblastoma and other solid tumours more …
CAR T cell killing requires the IFNγR pathway in solid but
We found that the loss of genes in the interferon-γ receptor (IFNγR) signalling pathway (IFNGR1, JAK1 or JAK2) rendered glioblastoma and other solid tumours more resistant to killing by CAR …
IFNγ Is Critical for CAR T Cell-Mediated Myeloid Activation and ...
IFNγ production by CAR T cells and IFNγ responsiveness of host immune cells are critical for tumor immune landscape remodeling to promote a more activated and less suppressive tumor …
Type I IFN Promotes IL-10 Production from T Cells to Suppress …
2011年12月6日 · Our data show that IFNβ treatment of T cells cultured under Th17 polarizing conditions resulted in reduced production of IL-17, but increased production of IL-10. We also …
Type I interferon transcriptional network regulates expression of ...
2022年3月17日 · In the present study, we show that type 1 interferon (IFN-I) regulates coinhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG-3 while inhibiting TIGIT …
FOXP3 + regulatory T cell perturbation mediated by the IFNγ
2024年1月2日 · Here, we showed that IFITM3-deficient Tregs blunted tumor growth by strengthening the tumor-killing response and displayed the Th1-like Treg phenotype with …
Model for the role of IFNR signaling in T-cell ... - ResearchGate
Here, we show that interferon gamma receptor deficient (IFNγR-/-) allogeneic Tconv, which possess normal allo-reactivity and cytotoxicity, induce significantly less GvHD than wild-type …
Type I Interferon-dependent T cell activation is mediated by IFN ...
2012年1月1日 · Taken together, we show that the IFNαR dependence of the CD4+ T cell response is accounted for exclusively by defects in DC activation. The type-I-interferon …
IFNγR Pathway Mediates CAR T Cell Cytotoxicity Against Solid
2022年6月2日 · IFNγR pathway disruption reduces the efficacy of CAR T cell killing in solid tumors.
Type I IFN-Dependent T Cell Activation Is Mediated by IFN …
2012年1月15日 · Taken together, we show that the IFNαR dependence of the CD4 + T cell response is accounted for exclusively by defects in DC activation. The type I IFN cytokine …