Phosphatidylcholine - Wikipedia
网页Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes and can be easily obtained from a variety of readily available sources, such as egg yolk or soybeans, from which they are mechanically or chemically extracted using hexane.
Phosphatidylcholine and Related Lipids - LIPID MAPS
网页Phosphatidylcholine is the main phospholipid circulating in plasma, where it is an integral component of the lipoproteins, especially the HDL. On the other hand, it is less often found in bacterial membranes, perhaps ~10% of species, and there is none in the 'model' organisms Escherichia coli and Bacillus subtilis.
The critical role of phosphatidylcholine and …
网页2017年9月1日 · Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co-workers performed groundbreaking research that established the general outline of many of the pathways of phospholipid biosynthesis.
The critical role of phosphatidylcholine and …
网页The relative abundance of PC and PE regulates the size and dynamics of lipid droplets. In mitochondria, changes in the PC/PE molar ratio affect energy production. We highlight data showing that changes in the PC and/or PE content of various tissues are implicated in metabolic disorders such as atherosclerosis, insulin resistance and obesity.
Phosphatidylcholine biosynthesis and lipoprotein metabolism
网页Phosphatidylcholine (PC) is the major phospholipid component of all plasma lipoprotein classes. PC is the only phospholipid which is currently known to be required for lipoprotein assembly and secretion. Impaired hepatic PC biosynthesis significantly reduces the levels of circulating very low densit ….
Phosphatidylcholine - an overview | ScienceDirect Topics
网页Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes and can be synthesized by either of two pathways, the methylation pathway or the CDP-choline pathway. Many prokaryotes lack PC, but it can be found in significant amounts in membranes of rather diverse bacteria and based on …
Phosphatidylcholine: Greasing the Cholesterol Transport Machinery
网页2016年4月4日 · Negative feedback regulation of cholesterol metabolism in mammalian cells ensures a proper balance of cholesterol with other membrane lipids, principal among these being the major phospholipid phosphatidylcholine (PC). Processes such as cholesterol biosynthesis and efflux, cholesteryl ester storage in lipid droplets, and uptake of plasma ...
Phosphatidylcholine and phosphatidylethanolamine plasmalogens …
网页2018年10月11日 · The PC to free cholesterol (FC) ratio was significantly decreased by treatment with both lipoproteins from 1.7 in macrophages to values around 0.7 to 0.8 in lipid loaded cells. Higher PC to FC ratios in control cells point towards more fluid membranes, while lower ratios in lipoprotein treated cells suggest a more rigid membrane structure.
Model Mechanism for Lipid Uptake by the Human STARD2/PC-TP ...
网页2024年8月6日 · StAR-related lipid transfer domain protein 2 (STARD2), also known as phosphatidylcholine transfer protein (PC-TP), is a single-domain protein in humans that has demonstrated the ability to extract phosphatidylcholine (PC) lipids from vesicles and microsomes, with a preference for PC lipids containing polyunsaturated tails.
The structural basis for the phospholipid remodeling by ...
网页2021年11月25日 · As the major component of cell membranes, phosphatidylcholine (PC) is synthesized de novo in the Kennedy pathway and then undergoes extensive deacylation-reacylation remodeling via Lands’ cycle.