Targeting PI3K/Akt signal transduction for cancer therapy
2021年12月16日 · The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is a major signaling pathway in various types of cancer. 1 It controls hallmarks of cancer, including cell...
PI3K/AKT pathway as a pivotal regulator of epithelial …
PI3K/AKT axis. Receptor tyrosine kinases (RTKs) have a fundamental role in regulation of cell proliferation, metabolism, migration, and apoptosis through the PI3K/AKT pathway [].It has been shown that PI3K/AKT pathway has a key role in regulation of EMT process during lung tumor metastasis (Fig. 1).Ephrin (Eph) is considered as the largest RTK subfamily that can be …
PI3K-Akt pathway: its functions and alterations in human cancer
Activation of Akt plays a pivotal role in fundamental cellular functions such as cell proliferation and survival by phosphorylating a variety of substrates. In recent years, it has been reported that alterations to the PI3K-Akt signaling pathway are frequent in human cancer.
Important Roles of PI3K/AKT Signaling Pathway and Relevant …
2024年11月1日 · Ezgi et al. discovered a crosstalk between the PI3K/AKT pathway and the Bcl-2 pathway , indicating that Bcl-2 is a downstream molecule of the PI3K/AKT pathway, thus providing a theoretical basis for the combined use of the two inhibitors. Erufosine (ErPC3) acts as an AKT inhibitor, inhibiting mTOR downstream activation by suppressing AKT ...
Targeting the PI3-kinase/Akt/mTOR Signaling Pathway - PMC
The PI3K/Akt/mTOR pathway can be targeted by a variety of approaches including: (i) targeting kinases that lead to activation of Akt, PI3K and PDK-1, (ii) directly targeting PI3K, (iii) directly inhibiting Akt, (iv) targeting downstream effectors of Akt …
PI3K Akt Pathway - Cell Signaling Technology
Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade.
PI3K/AKT Pathway - an overview | ScienceDirect Topics
The PI3K/AKT pathway is an intracellular signaling cascade with an indispensable effect on cell cycle. This pathway is functionally associated with cell proliferation, quiescence, and cancer [1]. PI3K can be triggered by receptor tyrosine kinases, …
PI3K signalling: the path to discovery and understanding
2012年2月23日 · The PI3K pathway can be mutationally activated (such as in cancer) or inactivated (such as in some myopathies, neuropathies and ciliopathies) and acts in immunity, metabolism and cardiac...
The PI3K–AKT network at the interface of oncogenic ... - Nature
2019年11月4日 · Understanding how the PI3K–AKT pathway governs metabolic networks in normal cells and how this control is altered in cancer cells could reveal metabolic vulnerabilities and thus inform new...
The PI3K Pathway in Human Disease - Cell Press
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer.
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